Triple-Helix Formation by α Oligodeoxynucleotides and α Oligodeoxynucleotide-Intercalator Conjugates

Base-pair sequences in double-stranded DNA can be recognized by homopyrimidine oligonucleotides that bind to the major groove at homopurine·homopyrimidine sequences thereby forming a local triple helix. To make oligodeoxynucleotides resistant to nucleases, we replaced the natural (β) anomers of the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1991-07, Vol.88 (14), p.6023-6027
Hauptverfasser:	Sun, J. S., Giovannangeli, C., Francois, J. C., Kurfurst, R., Montenay-Garestier, T., Asseline, U., Saison-Behmoaras, T., Thuong, N. T., Helene, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines AIDS/HIV Analytical, structural and metabolic biochemistry Base Sequence Biochemistry Biological and medical sciences Chemical bases DNA DNA - chemistry Dna, deoxyribonucleoproteins DNA, Viral - chemistry Enzymes Fundamental and applied biological sciences. Psychology HIV - genetics Hydrogen Bonding Hydrogen bonds Intercalating Agents Molecular Sequence Data Nucleic Acid Conformation Nucleic Acid Denaturation Nucleic acids Nucleotides Oligodeoxyribonucleotides - chemistry Oligomers Oligonucleotides Proviruses - genetics Thermodynamics
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