The Retinoblastoma Gene Functions as a Growth and Tumor Suppressor in Human Bladder Carcinoma Cells

The product of the human retinoblastoma gene (RB) is a nuclear phosphoprotein that is thought to function as a tumor suppressor. Mutations of RB frequently occur in human bladder carcinoma. To investigate the significance of the functional loss of this gene in bladder cancer, an RB expression plasmi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1991-06, Vol.88 (12), p.5257-5261
Hauptverfasser:	Takahashi, Rei, Hashimoto, Tomoko, Xu, Hong-Ji, Hu, Shi-Xu, Matsui, Toshimitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques Actins - genetics ANIMAL CELLS Animals Base Sequence BASIC BIOLOGICAL SCIENCES BIOCHEMISTRY Biological and medical sciences BLADDER Blotting, Northern BODY CARCINOMAS Cell growth Cell lines CHEMICAL REACTIONS CHEMISTRY Cultured cells CYTOCHEMISTRY DISEASES Fundamental and applied biological sciences. Psychology GENE MUTATIONS GENES Genes, Suppressor Genes. Genome GROWTH HeLa cells Humans Immunohistochemistry INHIBITION Mice Mice, Nude Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutation MUTATIONS NEOPLASMS ORGANIC COMPOUNDS ORGANS Phenotype PHOSPHOPROTEINS PHOSPHORYLATION Plasmids Promoter Regions, Genetic PROTEINS Retinoblastoma genes Retinoblastoma Protein - genetics RNA RNA, Neoplasm - analysis Transfection Tumor cell line TUMOR CELLS Tumor Cells, Cultured tumor suppressors Tumors Urinary bladder Urinary Bladder Neoplasms - pathology URINARY TRACT
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