Positive Darwinian Evolution in Human Influenza A Viruses

We earlier suggested that type A human influenza virus genes undergo positive Darwinian selection through immune surveillance. This requires more favorable amino acid replacements fixed in antigenic sites among the surviving lineages than among the extinct lineages. We now show that viral hemaggluti...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1991-05, Vol.88 (10), p.4270-4274
Hauptverfasser:	Fitch, Walter M., Josef M. E. Leiter, Li, Xingqiang, Palese, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Biological and medical sciences Biological Evolution Darwinism Evolution Fundamental and applied biological sciences. Psychology Genes, Viral Genetic mutation Genetics of eukaryotes. Biological and molecular evolution Hemagglutinins, Viral - chemistry Hemagglutinins, Viral - genetics Human influenza Influenza A virus Influenza A virus - genetics Molecular Sequence Data Nucleotides Positive selection Surveillance Viruses
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