Platelet Glycoprotein IIb-IIIa Protein Antagonists from Snake Venoms: Evidence for a Family of Platelet-Aggregation Inhibitors

The purification, complete amino acid sequence, and biological activity are described for several homologous snake venom proteins that are platelet glycoprotein (GP) IIb-IIIa antagonists and potent inhibitors of platelet aggregation. The primary structures of kistrin (from Agkistrodon rhodostoma), b...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1990-04, Vol.87 (7), p.2471-2475
Hauptverfasser:	Dennis, Mark S., Henzel, William J., Pitti, Robert M., Lipari, Michael T., Napier, Mary A., Deisher, Theresa A., Bunting, Stuart, Lazarus, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation Agkistrodon rhodostoma Amino Acid Sequence Amino acids Animals Biochemistry Biological and medical sciences Bitis arietans Blood coagulation. Blood cells Echis carinatus Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Humans Inhibitory concentration 50 Male Mass Spectrometry Molecular and cellular biology Molecular Sequence Data Platelet Platelet aggregation Platelet Aggregation Inhibitors Platelet Membrane Glycoproteins - antagonists & inhibitors Platelets Protein isoforms Proteins Rabbits Sequence Homology, Nucleic Acid Snake venoms Snake Venoms - isolation & purification Snake Venoms - pharmacology Trimeresusus gramineus venom Venoms
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