Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution

Human neutrophil elastase (HNE) has been implicated as a major contributor to tissue destruction in various disease states, including emphysema. The structure of HNE, at neutral pH, in complex with methoxysuccinyl-Ala-Ala-Pro-Ala chloromethyl ketone (MSACK), has been solved and refined to an R facto...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1989-01, Vol.86 (1), p.7-11
Hauptverfasser:	NAVIA, M. A, MCKEEVER, B. M, SPRINGER, J. P, TSAU-YEN LIN, WILLIAMS, H. R, FLUDER, E. M, DORN, C. P, HOOGSTEEN, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Chloromethyl Ketones - metabolism Binding Sites Biological and medical sciences Crystalline structure Fundamental and applied biological sciences. Psychology Humans Models, Molecular Molecular biophysics Neutrophils - enzymology Pancreatic Elastase - antagonists & inhibitors Pancreatic Elastase - blood Protein Binding Protein Conformation Sputum - enzymology Structure in molecular biology X-Ray Diffraction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!