Promotion of Murine Hepatocarcinogenesis by Testosterone is Androgen Receptor-Dependent but not Cell Autonomous

Tfm (testicular feminization) mutant mice lack functional androgen receptors. By studying liver tumor development in Tfm mice, we have shown that the greater susceptibility of male mice relative to female mice for liver tumor induction by N,N-diethylnitrosamine is androgen receptor-dependent. C57BL/...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1989-10, Vol.86 (19), p.7505-7509
Hauptverfasser:	Kemp, Christopher J., Leary, Cynthia N., Drinkwater, Norman R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Androgen receptors Androgen-Insensitivity Syndrome - genetics Animals Biological and medical sciences Cell physiology Diethylnitrosamine - toxicity Disease Susceptibility Female Female animals Fundamental and applied biological sciences. Psychology Hepatocytes Liver Liver - drug effects Liver - growth & development Liver - pathology Liver Neoplasms, Experimental - genetics Liver Neoplasms, Experimental - pathology Male Male animals Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Mutant Strains Molecular and cellular biology Mosaic Mutation Ovariectomy Precancerous Conditions - pathology Receptors Receptors, Androgen - analysis Receptors, Androgen - genetics Responses to growth factors, tumor promotors, other factors Testosterone Testosterone - pharmacology Tumors X Chromosome
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