Changes in Brain Gene Expression Shared by Scrapie and Alzheimer Disease
We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1989-09, Vol.86 (18), p.7260-7264 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7264 |
|---|---|
| container_issue | 18 |
| container_start_page | 7260 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 86 |
| creator | Duguid, John R. Bohmont, Craig W. Liu, Ningai Tourtellotte, Wallace W. |
| description | We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease and Pick disease, whereas transferrin RNA is not strongly modulated in these conditions. Expression of two previously identified scrapie-modulated genes, encoding glial fibrillary acidic protein and metallothionein, is also increased in both of these neurodegenerative diseases. |
| doi_str_mv | 10.1073/pnas.86.18.7260 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pnas_</sourceid><recordid>TN_cdi_pnas_primary_86_18_7260_fulltext</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>34441</jstor_id><sourcerecordid>34441</sourcerecordid><originalsourceid>FETCH-LOGICAL-c588t-3b14b6275dbc579435d36ab5c0f754e29b86a20b26deeb92113170a7dc9a4e153</originalsourceid><addsrcrecordid>eNqFkTtvFDEUhS0ECkugRkICTQNUs_H7UVCEJSRIkSgCteXx3Mk6mvVM7FmU8OvxaoeFNNDYxfnOvefqIPSS4CXBip2M0eWllkuil4pK_AgtCDakltzgx2iBMVW15pQ_Rc9yvsEYG6HxETqiSmOh8AJdrNYuXkOuQqw-Jlfec4hQnd2NCXIOQ6yu1i5BWzX31ZVPbgxQudhWp_3PNYQNpOpTyOAyPEdPOtdneDH_x-j757Nvq4v68uv5l9XpZe2F1lPNGsIbSZVoGy-U4Uy0TLpGeNwpwYGaRktHcUNlC9AYSggjCjvVeuM4EMGO0Yf93HHbbKD1EKfkejumsHHp3g4u2IdKDGt7Pfyw1GjMVPG_m_1puN1CnuwmZA997yIM22xV2clLlP-CJQtTWpkCnuxBn4acE3SHMATbXUl2V5LV0hJtdyUVx-u_bzjwcytFfzvrLnvXd8lFH_KfsYZxJQUt3JuZ2y34LT9Y9P6fgO22fT_B3VTIV3vyJk9DOqCMc07YL4b3uz4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15337879</pqid></control><display><type>article</type><title>Changes in Brain Gene Expression Shared by Scrapie and Alzheimer Disease</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Duguid, John R. ; Bohmont, Craig W. ; Liu, Ningai ; Tourtellotte, Wallace W.</creator><creatorcontrib>Duguid, John R. ; Bohmont, Craig W. ; Liu, Ningai ; Tourtellotte, Wallace W.</creatorcontrib><description>We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease and Pick disease, whereas transferrin RNA is not strongly modulated in these conditions. Expression of two previously identified scrapie-modulated genes, encoding glial fibrillary acidic protein and metallothionein, is also increased in both of these neurodegenerative diseases.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.86.18.7260</identifier><identifier>PMID: 2780570</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Alzheimer Disease - genetics ; Alzheimer Disease - metabolism ; Alzheimer's disease ; Alzheimers disease ; Animals ; Base Sequence ; Biological and medical sciences ; brain ; Brain - metabolism ; Clusterin ; Cricetinae ; DNA ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Genes ; Glial Fibrillary Acidic Protein - genetics ; glycoproteins ; Glycoproteins - genetics ; Libraries ; Messenger RNA ; Metallothionein - genetics ; Molecular and cellular biology ; Molecular Chaperones ; Molecular genetics ; Molecular Sequence Data ; Nerve Tissue Proteins - genetics ; Nervous system diseases ; Neurodegenerative diseases ; Nucleic acids ; Rats ; RNA ; RNA, Messenger - genetics ; Scrapie - genetics ; Scrapie - metabolism ; Sequence Homology, Nucleic Acid ; Transcription, Genetic ; transferrin ; Transferrin - genetics ; Transferrins</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1989-09, Vol.86 (18), p.7260-7264</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588t-3b14b6275dbc579435d36ab5c0f754e29b86a20b26deeb92113170a7dc9a4e153</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/86/18.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/34441$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/34441$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,728,781,785,804,886,27926,27927,53793,53795,58019,58252</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19347652$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2780570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duguid, John R.</creatorcontrib><creatorcontrib>Bohmont, Craig W.</creatorcontrib><creatorcontrib>Liu, Ningai</creatorcontrib><creatorcontrib>Tourtellotte, Wallace W.</creatorcontrib><title>Changes in Brain Gene Expression Shared by Scrapie and Alzheimer Disease</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease and Pick disease, whereas transferrin RNA is not strongly modulated in these conditions. Expression of two previously identified scrapie-modulated genes, encoding glial fibrillary acidic protein and metallothionein, is also increased in both of these neurodegenerative diseases.</description><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer's disease</subject><subject>Alzheimers disease</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>brain</subject><subject>Brain - metabolism</subject><subject>Clusterin</subject><subject>Cricetinae</subject><subject>DNA</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Glial Fibrillary Acidic Protein - genetics</subject><subject>glycoproteins</subject><subject>Glycoproteins - genetics</subject><subject>Libraries</subject><subject>Messenger RNA</subject><subject>Metallothionein - genetics</subject><subject>Molecular and cellular biology</subject><subject>Molecular Chaperones</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nervous system diseases</subject><subject>Neurodegenerative diseases</subject><subject>Nucleic acids</subject><subject>Rats</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>Scrapie - genetics</subject><subject>Scrapie - metabolism</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Transcription, Genetic</subject><subject>transferrin</subject><subject>Transferrin - genetics</subject><subject>Transferrins</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtvFDEUhS0ECkugRkICTQNUs_H7UVCEJSRIkSgCteXx3Mk6mvVM7FmU8OvxaoeFNNDYxfnOvefqIPSS4CXBip2M0eWllkuil4pK_AgtCDakltzgx2iBMVW15pQ_Rc9yvsEYG6HxETqiSmOh8AJdrNYuXkOuQqw-Jlfec4hQnd2NCXIOQ6yu1i5BWzX31ZVPbgxQudhWp_3PNYQNpOpTyOAyPEdPOtdneDH_x-j757Nvq4v68uv5l9XpZe2F1lPNGsIbSZVoGy-U4Uy0TLpGeNwpwYGaRktHcUNlC9AYSggjCjvVeuM4EMGO0Yf93HHbbKD1EKfkejumsHHp3g4u2IdKDGt7Pfyw1GjMVPG_m_1puN1CnuwmZA997yIM22xV2clLlP-CJQtTWpkCnuxBn4acE3SHMATbXUl2V5LV0hJtdyUVx-u_bzjwcytFfzvrLnvXd8lFH_KfsYZxJQUt3JuZ2y34LT9Y9P6fgO22fT_B3VTIV3vyJk9DOqCMc07YL4b3uz4</recordid><startdate>19890901</startdate><enddate>19890901</enddate><creator>Duguid, John R.</creator><creator>Bohmont, Craig W.</creator><creator>Liu, Ningai</creator><creator>Tourtellotte, Wallace W.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T3</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19890901</creationdate><title>Changes in Brain Gene Expression Shared by Scrapie and Alzheimer Disease</title><author>Duguid, John R. ; Bohmont, Craig W. ; Liu, Ningai ; Tourtellotte, Wallace W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-3b14b6275dbc579435d36ab5c0f754e29b86a20b26deeb92113170a7dc9a4e153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer's disease</topic><topic>Alzheimers disease</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>brain</topic><topic>Brain - metabolism</topic><topic>Clusterin</topic><topic>Cricetinae</topic><topic>DNA</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Glial Fibrillary Acidic Protein - genetics</topic><topic>glycoproteins</topic><topic>Glycoproteins - genetics</topic><topic>Libraries</topic><topic>Messenger RNA</topic><topic>Metallothionein - genetics</topic><topic>Molecular and cellular biology</topic><topic>Molecular Chaperones</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nervous system diseases</topic><topic>Neurodegenerative diseases</topic><topic>Nucleic acids</topic><topic>Rats</topic><topic>RNA</topic><topic>RNA, Messenger - genetics</topic><topic>Scrapie - genetics</topic><topic>Scrapie - metabolism</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Transcription, Genetic</topic><topic>transferrin</topic><topic>Transferrin - genetics</topic><topic>Transferrins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duguid, John R.</creatorcontrib><creatorcontrib>Bohmont, Craig W.</creatorcontrib><creatorcontrib>Liu, Ningai</creatorcontrib><creatorcontrib>Tourtellotte, Wallace W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Human Genome Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duguid, John R.</au><au>Bohmont, Craig W.</au><au>Liu, Ningai</au><au>Tourtellotte, Wallace W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in Brain Gene Expression Shared by Scrapie and Alzheimer Disease</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1989-09-01</date><risdate>1989</risdate><volume>86</volume><issue>18</issue><spage>7260</spage><epage>7264</epage><pages>7260-7264</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease and Pick disease, whereas transferrin RNA is not strongly modulated in these conditions. Expression of two previously identified scrapie-modulated genes, encoding glial fibrillary acidic protein and metallothionein, is also increased in both of these neurodegenerative diseases.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>2780570</pmid><doi>10.1073/pnas.86.18.7260</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1989-09, Vol.86 (18), p.7260-7264 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pnas_primary_86_18_7260_fulltext |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Alzheimers disease Animals Base Sequence Biological and medical sciences brain Brain - metabolism Clusterin Cricetinae DNA Fundamental and applied biological sciences. Psychology Gene expression Genes Glial Fibrillary Acidic Protein - genetics glycoproteins Glycoproteins - genetics Libraries Messenger RNA Metallothionein - genetics Molecular and cellular biology Molecular Chaperones Molecular genetics Molecular Sequence Data Nerve Tissue Proteins - genetics Nervous system diseases Neurodegenerative diseases Nucleic acids Rats RNA RNA, Messenger - genetics Scrapie - genetics Scrapie - metabolism Sequence Homology, Nucleic Acid Transcription, Genetic transferrin Transferrin - genetics Transferrins |
| title | Changes in Brain Gene Expression Shared by Scrapie and Alzheimer Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T12%3A52%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pnas_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Changes%20in%20Brain%20Gene%20Expression%20Shared%20by%20Scrapie%20and%20Alzheimer%20Disease&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Duguid,%20John%20R.&rft.date=1989-09-01&rft.volume=86&rft.issue=18&rft.spage=7260&rft.epage=7264&rft.pages=7260-7264&rft.issn=0027-8424&rft.eissn=1091-6490&rft.coden=PNASA6&rft_id=info:doi/10.1073/pnas.86.18.7260&rft_dat=%3Cjstor_pnas_%3E34441%3C/jstor_pnas_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15337879&rft_id=info:pmid/2780570&rft_jstor_id=34441&rfr_iscdi=true |