Isolation and Characterization of Human Defensin cDNA Clones

Four clones that encode defensins, a group of microbicidal and cytotoxic peptides made by neutrophils, were isolated from an HL-60 human promyelocytic leukemia cDNA library. Analysis of these clones indicated that the defensins are made as precursor proteins, which must be cleaved to yield the matur...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1988-10, Vol.85 (19), p.7327-7331
Hauptverfasser:	Daher, Kathleen A., Lehrer, Robert I., Ganz, Tomas, Kronenberg, Mitchell
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques Amino Acid Sequence Amino acids AUTORADIOGRAPHY BACTERIA Base Sequence BASIC BIOLOGICAL SCIENCES BIOLOGICAL MATERIALS BLOOD BLOOD CELLS Blood Proteins - genetics BODY FLUIDS Cell Line Cell lines CLONING Cloning, Molecular Complementary DNA Defensins Dimethyl Sulfoxide - pharmacology DISEASES DMSO DNA DNA - isolation & purification DNA HYBRIDIZATION DNA-CLONING ESCHERICHIA COLI GENE REGULATION Hematopoietic stem cells HEMIC DISEASES Humans HYBRIDIZATION IMMUNE SYSTEM DISEASES IMMUNITY LEUKEMIA Leukemia, Promyelocytic, Acute - genetics LEUKOCYTES Lymphocytes MATERIALS MESSENGER-RNA MICROORGANISMS Molecular Sequence Data MOLECULAR STRUCTURE Myeloid cells NEOPLASMS Neutrophils Neutrophils - drug effects NUCLEIC ACIDS ORGANIC COMPOUNDS ORGANIC SULFUR COMPOUNDS PATIENTS PEPTIDES PROTEINS RECOMBINANT DNA RNA RNA, Messenger - analysis SULFOXIDES
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