Somatic Diversification of the S107 (T15) VH11 Germ-Line Gene that Encodes the Heavy-Chain Variable Region of Antibodies to Double-Stranded DNA in (NZB × NZW)F1 Mice

A variety of studies suggest that members of the S107 (T15) heavy-chain variable-region gene family contribute to the autoimmune response of mice and humans to DNA. To identify the germ-line gene(s) involved and the degree of somatic diversification that occurs in such autoantibodies, we determined...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1988-06, Vol.85 (11), p.3970-3974
Hauptverfasser:	Behar, S. M., Scharff, M. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal - genetics Antibody Diversity Antigens Autoantibodies Autoantibodies - genetics Autoimmunity (experimental aspects and models) B lymphocytes Base Sequence Biological and medical sciences Cloning, Molecular DNA DNA - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Genes, Immunoglobulin Genetic mutation Hybridomas Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics Liver Messenger RNA Mice Mice, Inbred Strains Molecular Sequence Data Monoclonal antibodies RNA, Messenger - genetics
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