Isolation and Characterization of Lymphokine cDNA Clones Encoding Mouse and Human IgA-Enhancing Factor and Eosinophil Colony-Stimulating Factor Activities: Relationship to Interleukin 5
Conditioned medium from the Con A-treated mouse helper T-cell clone Ly1+2-/9 contains activities that enhance the production of IgA by mouse B cells and induce human cord blood cells to form eosinophil colonies. We have isolated a cDNA sequence that expresses IgA-enhancing factor and eosinophil colo...
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| Veröffentlicht in: | Proc. Natl. Acad. Sci. U.S.A.; (United States) 1987-11, Vol.84 (21), p.7388-7392 |
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| container_title | Proc. Natl. Acad. Sci. U.S.A.; (United States) |
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| creator | Yokota, Takashi Coffman, Robert L. Hagiwara, Hajime Rennick, Donna M. Takebe, Yutaka Yokota, Kyoko Gemmell, Lorraine Shrader, Barbara Yang, Gloria Meyerson, Patricia Luh, Jeanne Hoy, Pamala Pène, Jérome Brière, Francine Spits, Hergen Banchereau, Jacques De Vries, Jan Lee, Frank D. Arai, Naoko Arai, Ken-Ichi |
| description | Conditioned medium from the Con A-treated mouse helper T-cell clone Ly1+2-/9 contains activities that enhance the production of IgA by mouse B cells and induce human cord blood cells to form eosinophil colonies. We have isolated a cDNA sequence that expresses IgA-enhancing factor and eosinophil colony-stimulating factor activities from a cDNA library prepared from activated Ly1+2-/9 cells. Based on homology with the mouse cDNA sequence, a human cDNA sequence coding for an interleukin with IgA-enhancing factor and eosinophil colony-stimulating factor activities was isolated from a cDNA library prepared from a human T-cell clone stimulated with anti-T3 antibody and phorbol 12-myristate 13-acetate. DNA sequence analyses revealed that mouse and human cDNA clones encode proteins of 133 and 134 amino acids, respectively, that are identical to cDNA clones encoding the T-cell replacing factor I and B-cell growth factor II activities. These results establish that a single cDNA clone encodes a protein that acts as a growth and differentiation factor for both B cells and eosinophils. |
| doi_str_mv | 10.1073/pnas.84.21.7388 |
| format | Article |
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We have isolated a cDNA sequence that expresses IgA-enhancing factor and eosinophil colony-stimulating factor activities from a cDNA library prepared from activated Ly1+2-/9 cells. Based on homology with the mouse cDNA sequence, a human cDNA sequence coding for an interleukin with IgA-enhancing factor and eosinophil colony-stimulating factor activities was isolated from a cDNA library prepared from a human T-cell clone stimulated with anti-T3 antibody and phorbol 12-myristate 13-acetate. DNA sequence analyses revealed that mouse and human cDNA clones encode proteins of 133 and 134 amino acids, respectively, that are identical to cDNA clones encoding the T-cell replacing factor I and B-cell growth factor II activities. These results establish that a single cDNA clone encodes a protein that acts as a growth and differentiation factor for both B cells and eosinophils.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.84.21.7388</identifier><identifier>PMID: 2823259</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>AMINO ACID SEQUENCE ; AMINO ACIDS ; Analysis of the immune response. Humoral and cellular immunity ; ANIMAL CELLS ; ANIMALS ; AUTORADIOGRAPHY ; B lymphocytes ; BASIC BIOLOGICAL SCIENCES ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; Biological and medical sciences ; BIOLOGICAL MATERIALS ; BLOOD ; BLOOD CELLS ; BODY FLUIDS ; BONE MARROW CELLS ; CARBOXYLIC ACIDS ; CARCINOGENS ; cDNA ; CDNA libraries ; CELL DIFFERENTIATION ; Cell Line ; Cloning, Molecular ; colony-stimulating factors ; Colony-Stimulating Factors - genetics ; Complementary DNA ; CONNECTIVE TISSUE CELLS ; COS cells ; DAYS LIVING RADIOISOTOPES ; DNA ; DNA - isolation & purification ; DNA Restriction Enzymes ; DNA SEQUENCING ; DRUGS ; ELECTROPHORESIS ; eosinophil ; EOSINOPHILS ; ESTERS ; EVEN-ODD NUCLEI ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; genes ; GLOBULINS ; GROWTH ; GROWTH FACTORS ; Humans ; Immunobiology ; immunoglobulin A ; IMMUNOGLOBULINS ; Interleukin-5 ; Interleukins - genetics ; ISOTOPES ; LEUKOCYTES ; LIGHT NUCLEI ; LIPOTROPIC FACTORS ; LYMPHOCYTES ; LYMPHOKINES ; Lymphokines - genetics ; Lymphokines, interleukins ( function, expression) ; MAMMALS ; MAN ; MATERIALS ; Messenger RNA ; METHIONINE ; MICE ; MITOGENS ; Molecular Sequence Data ; MOLECULAR STRUCTURE ; NUCLEI ; NUCLEIC ACIDS ; ODD-ODD NUCLEI ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANIC SULFUR COMPOUNDS ; PHORBOL ESTERS ; PHOSPHORUS 32 ; PHOSPHORUS ISOTOPES ; PRIMATES ; Prostatic Secretory Proteins ; PROTEINS ; RADIOISOTOPES ; RECOMBINANT DNA ; Regulatory factors and their cellular receptors ; RNA, Messenger - genetics ; RNA, Messenger - isolation & purification ; RODENTS ; SOMATIC CELLS ; Spleen cells ; STRUCTURAL CHEMICAL ANALYSIS ; SULFUR 35 ; SULFUR ISOTOPES ; T lymphocytes ; VERTEBRATES 550201 -- Biochemistry-- Tracer Techniques</subject><ispartof>Proc. Natl. Acad. Sci. U.S.A.; (United States), 1987-11, Vol.84 (21), p.7388-7392</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c614t-8a2b8b9afdc16d454083d7d2b0e393a2057edb56484fc330d73f21570b792c2c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/84/21.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30825$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30825$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7426414$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2823259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6771406$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Yokota, Takashi</creatorcontrib><creatorcontrib>Coffman, Robert L.</creatorcontrib><creatorcontrib>Hagiwara, Hajime</creatorcontrib><creatorcontrib>Rennick, Donna M.</creatorcontrib><creatorcontrib>Takebe, Yutaka</creatorcontrib><creatorcontrib>Yokota, Kyoko</creatorcontrib><creatorcontrib>Gemmell, Lorraine</creatorcontrib><creatorcontrib>Shrader, Barbara</creatorcontrib><creatorcontrib>Yang, Gloria</creatorcontrib><creatorcontrib>Meyerson, Patricia</creatorcontrib><creatorcontrib>Luh, Jeanne</creatorcontrib><creatorcontrib>Hoy, Pamala</creatorcontrib><creatorcontrib>Pène, Jérome</creatorcontrib><creatorcontrib>Brière, Francine</creatorcontrib><creatorcontrib>Spits, Hergen</creatorcontrib><creatorcontrib>Banchereau, Jacques</creatorcontrib><creatorcontrib>De Vries, Jan</creatorcontrib><creatorcontrib>Lee, Frank D.</creatorcontrib><creatorcontrib>Arai, Naoko</creatorcontrib><creatorcontrib>Arai, Ken-Ichi</creatorcontrib><creatorcontrib>DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA (USA)</creatorcontrib><title>Isolation and Characterization of Lymphokine cDNA Clones Encoding Mouse and Human IgA-Enhancing Factor and Eosinophil Colony-Stimulating Factor Activities: Relationship to Interleukin 5</title><title>Proc. Natl. Acad. Sci. U.S.A.; (United States)</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Conditioned medium from the Con A-treated mouse helper T-cell clone Ly1+2-/9 contains activities that enhance the production of IgA by mouse B cells and induce human cord blood cells to form eosinophil colonies. We have isolated a cDNA sequence that expresses IgA-enhancing factor and eosinophil colony-stimulating factor activities from a cDNA library prepared from activated Ly1+2-/9 cells. Based on homology with the mouse cDNA sequence, a human cDNA sequence coding for an interleukin with IgA-enhancing factor and eosinophil colony-stimulating factor activities was isolated from a cDNA library prepared from a human T-cell clone stimulated with anti-T3 antibody and phorbol 12-myristate 13-acetate. DNA sequence analyses revealed that mouse and human cDNA clones encode proteins of 133 and 134 amino acids, respectively, that are identical to cDNA clones encoding the T-cell replacing factor I and B-cell growth factor II activities. These results establish that a single cDNA clone encodes a protein that acts as a growth and differentiation factor for both B cells and eosinophils.</description><subject>AMINO ACID SEQUENCE</subject><subject>AMINO ACIDS</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>ANIMAL CELLS</subject><subject>ANIMALS</subject><subject>AUTORADIOGRAPHY</subject><subject>B lymphocytes</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BLOOD</subject><subject>BLOOD CELLS</subject><subject>BODY FLUIDS</subject><subject>BONE MARROW CELLS</subject><subject>CARBOXYLIC ACIDS</subject><subject>CARCINOGENS</subject><subject>cDNA</subject><subject>CDNA libraries</subject><subject>CELL DIFFERENTIATION</subject><subject>Cell Line</subject><subject>Cloning, Molecular</subject><subject>colony-stimulating factors</subject><subject>Colony-Stimulating Factors - genetics</subject><subject>Complementary DNA</subject><subject>CONNECTIVE TISSUE CELLS</subject><subject>COS cells</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DNA</subject><subject>DNA - isolation & purification</subject><subject>DNA Restriction Enzymes</subject><subject>DNA SEQUENCING</subject><subject>DRUGS</subject><subject>ELECTROPHORESIS</subject><subject>eosinophil</subject><subject>EOSINOPHILS</subject><subject>ESTERS</subject><subject>EVEN-ODD NUCLEI</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>genes</subject><subject>GLOBULINS</subject><subject>GROWTH</subject><subject>GROWTH FACTORS</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>immunoglobulin A</subject><subject>IMMUNOGLOBULINS</subject><subject>Interleukin-5</subject><subject>Interleukins - genetics</subject><subject>ISOTOPES</subject><subject>LEUKOCYTES</subject><subject>LIGHT NUCLEI</subject><subject>LIPOTROPIC FACTORS</subject><subject>LYMPHOCYTES</subject><subject>LYMPHOKINES</subject><subject>Lymphokines - genetics</subject><subject>Lymphokines, interleukins ( function, expression)</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>MATERIALS</subject><subject>Messenger RNA</subject><subject>METHIONINE</subject><subject>MICE</subject><subject>MITOGENS</subject><subject>Molecular Sequence Data</subject><subject>MOLECULAR STRUCTURE</subject><subject>NUCLEI</subject><subject>NUCLEIC ACIDS</subject><subject>ODD-ODD NUCLEI</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC SULFUR COMPOUNDS</subject><subject>PHORBOL ESTERS</subject><subject>PHOSPHORUS 32</subject><subject>PHOSPHORUS ISOTOPES</subject><subject>PRIMATES</subject><subject>Prostatic Secretory Proteins</subject><subject>PROTEINS</subject><subject>RADIOISOTOPES</subject><subject>RECOMBINANT DNA</subject><subject>Regulatory factors and their cellular receptors</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - isolation & purification</subject><subject>RODENTS</subject><subject>SOMATIC CELLS</subject><subject>Spleen cells</subject><subject>STRUCTURAL CHEMICAL ANALYSIS</subject><subject>SULFUR 35</subject><subject>SULFUR ISOTOPES</subject><subject>T lymphocytes</subject><subject>VERTEBRATES 550201 -- Biochemistry-- Tracer Techniques</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuP0zAUhSMEGsrAGgkJZCEEq3T8SuwgsahKh6lUQOKxtlzHaTwkdiZ2RpR_xr_DmZQObGBlyee79x77niR5jOAcQUbOOiv9nNM5RnNGOL-TzBAsUJrTAt5NZhBilnKK6f3kgfeXEMIi4_AkOcEcE5wVs-Tn2rtGBuMskLYEy1r2UgXdmx_TpavAZt92tftmrAbq7YcFWDbOag9WVrnS2B147wavb6ovhlZasN4t0pWtpVWjeh7buf5GXjlvrOtq04Cli0326edg2mEcfwsuVDDXJhjtX4NPerLma9OB4MDaRmeNHqIXkD1M7lWy8frR4TxNvp6vviwv0s3Hd-vlYpOqHNGQcom3fFvIqlQoL2lGISclK_EWalIQiWHGdLnNcspppQiBJSMVRhmDW1ZghRU5Td5Mfbth2-pSaRt62YiuN63s98JJI_5WrKnFzl0LXBQEolj_fKp3PhjhlQla1cpZq1UQOWOIwjxCLw9Denc1aB9Ea7zSTSOtjt8rOII87pH9F0SUw4KzLIJnE6h6532vq6NjBMUYHTFGR3AqMBJjdGLF0z8feuQPWYn6i4MuvZJN1Y8b9keMUZxTRCP26oCN_X-rt3NENTRN0N9DJJ_9k4zAkwm49DEaR4JAjjPyC8av8Po</recordid><startdate>19871101</startdate><enddate>19871101</enddate><creator>Yokota, Takashi</creator><creator>Coffman, Robert L.</creator><creator>Hagiwara, Hajime</creator><creator>Rennick, Donna M.</creator><creator>Takebe, Yutaka</creator><creator>Yokota, Kyoko</creator><creator>Gemmell, Lorraine</creator><creator>Shrader, Barbara</creator><creator>Yang, Gloria</creator><creator>Meyerson, Patricia</creator><creator>Luh, Jeanne</creator><creator>Hoy, Pamala</creator><creator>Pène, Jérome</creator><creator>Brière, Francine</creator><creator>Spits, Hergen</creator><creator>Banchereau, Jacques</creator><creator>De Vries, Jan</creator><creator>Lee, Frank D.</creator><creator>Arai, Naoko</creator><creator>Arai, Ken-Ichi</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19871101</creationdate><title>Isolation and Characterization of Lymphokine cDNA Clones Encoding Mouse and Human IgA-Enhancing Factor and Eosinophil Colony-Stimulating Factor Activities: Relationship to Interleukin 5</title><author>Yokota, Takashi ; Coffman, Robert L. ; Hagiwara, Hajime ; Rennick, Donna M. ; Takebe, Yutaka ; Yokota, Kyoko ; Gemmell, Lorraine ; Shrader, Barbara ; Yang, Gloria ; Meyerson, Patricia ; Luh, Jeanne ; Hoy, Pamala ; Pène, Jérome ; Brière, Francine ; Spits, Hergen ; Banchereau, Jacques ; De Vries, Jan ; Lee, Frank D. ; Arai, Naoko ; Arai, Ken-Ichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c614t-8a2b8b9afdc16d454083d7d2b0e393a2057edb56484fc330d73f21570b792c2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>AMINO ACID SEQUENCE</topic><topic>AMINO ACIDS</topic><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>ANIMAL CELLS</topic><topic>ANIMALS</topic><topic>AUTORADIOGRAPHY</topic><topic>B lymphocytes</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BLOOD</topic><topic>BLOOD CELLS</topic><topic>BODY FLUIDS</topic><topic>BONE MARROW CELLS</topic><topic>CARBOXYLIC ACIDS</topic><topic>CARCINOGENS</topic><topic>cDNA</topic><topic>CDNA libraries</topic><topic>CELL DIFFERENTIATION</topic><topic>Cell Line</topic><topic>Cloning, Molecular</topic><topic>colony-stimulating factors</topic><topic>Colony-Stimulating Factors - genetics</topic><topic>Complementary DNA</topic><topic>CONNECTIVE TISSUE CELLS</topic><topic>COS cells</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DNA</topic><topic>DNA - isolation & purification</topic><topic>DNA Restriction Enzymes</topic><topic>DNA SEQUENCING</topic><topic>DRUGS</topic><topic>ELECTROPHORESIS</topic><topic>eosinophil</topic><topic>EOSINOPHILS</topic><topic>ESTERS</topic><topic>EVEN-ODD NUCLEI</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>genes</topic><topic>GLOBULINS</topic><topic>GROWTH</topic><topic>GROWTH FACTORS</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>immunoglobulin A</topic><topic>IMMUNOGLOBULINS</topic><topic>Interleukin-5</topic><topic>Interleukins - genetics</topic><topic>ISOTOPES</topic><topic>LEUKOCYTES</topic><topic>LIGHT NUCLEI</topic><topic>LIPOTROPIC FACTORS</topic><topic>LYMPHOCYTES</topic><topic>LYMPHOKINES</topic><topic>Lymphokines - genetics</topic><topic>Lymphokines, interleukins ( function, expression)</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>MATERIALS</topic><topic>Messenger RNA</topic><topic>METHIONINE</topic><topic>MICE</topic><topic>MITOGENS</topic><topic>Molecular Sequence Data</topic><topic>MOLECULAR STRUCTURE</topic><topic>NUCLEI</topic><topic>NUCLEIC ACIDS</topic><topic>ODD-ODD NUCLEI</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC SULFUR COMPOUNDS</topic><topic>PHORBOL ESTERS</topic><topic>PHOSPHORUS 32</topic><topic>PHOSPHORUS ISOTOPES</topic><topic>PRIMATES</topic><topic>Prostatic Secretory Proteins</topic><topic>PROTEINS</topic><topic>RADIOISOTOPES</topic><topic>RECOMBINANT DNA</topic><topic>Regulatory factors and their cellular receptors</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - isolation & purification</topic><topic>RODENTS</topic><topic>SOMATIC CELLS</topic><topic>Spleen cells</topic><topic>STRUCTURAL CHEMICAL ANALYSIS</topic><topic>SULFUR 35</topic><topic>SULFUR ISOTOPES</topic><topic>T lymphocytes</topic><topic>VERTEBRATES 550201 -- Biochemistry-- Tracer Techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yokota, Takashi</creatorcontrib><creatorcontrib>Coffman, Robert L.</creatorcontrib><creatorcontrib>Hagiwara, Hajime</creatorcontrib><creatorcontrib>Rennick, Donna M.</creatorcontrib><creatorcontrib>Takebe, Yutaka</creatorcontrib><creatorcontrib>Yokota, Kyoko</creatorcontrib><creatorcontrib>Gemmell, Lorraine</creatorcontrib><creatorcontrib>Shrader, Barbara</creatorcontrib><creatorcontrib>Yang, Gloria</creatorcontrib><creatorcontrib>Meyerson, Patricia</creatorcontrib><creatorcontrib>Luh, Jeanne</creatorcontrib><creatorcontrib>Hoy, Pamala</creatorcontrib><creatorcontrib>Pène, Jérome</creatorcontrib><creatorcontrib>Brière, Francine</creatorcontrib><creatorcontrib>Spits, Hergen</creatorcontrib><creatorcontrib>Banchereau, Jacques</creatorcontrib><creatorcontrib>De Vries, Jan</creatorcontrib><creatorcontrib>Lee, Frank D.</creatorcontrib><creatorcontrib>Arai, Naoko</creatorcontrib><creatorcontrib>Arai, Ken-Ichi</creatorcontrib><creatorcontrib>DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA (USA)</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proc. Natl. Acad. Sci. U.S.A.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yokota, Takashi</au><au>Coffman, Robert L.</au><au>Hagiwara, Hajime</au><au>Rennick, Donna M.</au><au>Takebe, Yutaka</au><au>Yokota, Kyoko</au><au>Gemmell, Lorraine</au><au>Shrader, Barbara</au><au>Yang, Gloria</au><au>Meyerson, Patricia</au><au>Luh, Jeanne</au><au>Hoy, Pamala</au><au>Pène, Jérome</au><au>Brière, Francine</au><au>Spits, Hergen</au><au>Banchereau, Jacques</au><au>De Vries, Jan</au><au>Lee, Frank D.</au><au>Arai, Naoko</au><au>Arai, Ken-Ichi</au><aucorp>DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA (USA)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation and Characterization of Lymphokine cDNA Clones Encoding Mouse and Human IgA-Enhancing Factor and Eosinophil Colony-Stimulating Factor Activities: Relationship to Interleukin 5</atitle><jtitle>Proc. Natl. Acad. Sci. U.S.A.; (United States)</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1987-11-01</date><risdate>1987</risdate><volume>84</volume><issue>21</issue><spage>7388</spage><epage>7392</epage><pages>7388-7392</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Conditioned medium from the Con A-treated mouse helper T-cell clone Ly1+2-/9 contains activities that enhance the production of IgA by mouse B cells and induce human cord blood cells to form eosinophil colonies. We have isolated a cDNA sequence that expresses IgA-enhancing factor and eosinophil colony-stimulating factor activities from a cDNA library prepared from activated Ly1+2-/9 cells. Based on homology with the mouse cDNA sequence, a human cDNA sequence coding for an interleukin with IgA-enhancing factor and eosinophil colony-stimulating factor activities was isolated from a cDNA library prepared from a human T-cell clone stimulated with anti-T3 antibody and phorbol 12-myristate 13-acetate. DNA sequence analyses revealed that mouse and human cDNA clones encode proteins of 133 and 134 amino acids, respectively, that are identical to cDNA clones encoding the T-cell replacing factor I and B-cell growth factor II activities. These results establish that a single cDNA clone encodes a protein that acts as a growth and differentiation factor for both B cells and eosinophils.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>2823259</pmid><doi>10.1073/pnas.84.21.7388</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proc. Natl. Acad. Sci. U.S.A.; (United States), 1987-11, Vol.84 (21), p.7388-7392 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pnas_primary_84_21_7388_fulltext |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | AMINO ACID SEQUENCE AMINO ACIDS Analysis of the immune response. Humoral and cellular immunity ANIMAL CELLS ANIMALS AUTORADIOGRAPHY B lymphocytes BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BODY FLUIDS BONE MARROW CELLS CARBOXYLIC ACIDS CARCINOGENS cDNA CDNA libraries CELL DIFFERENTIATION Cell Line Cloning, Molecular colony-stimulating factors Colony-Stimulating Factors - genetics Complementary DNA CONNECTIVE TISSUE CELLS COS cells DAYS LIVING RADIOISOTOPES DNA DNA - isolation & purification DNA Restriction Enzymes DNA SEQUENCING DRUGS ELECTROPHORESIS eosinophil EOSINOPHILS ESTERS EVEN-ODD NUCLEI Fundamental and applied biological sciences. Psychology Fundamental immunology genes GLOBULINS GROWTH GROWTH FACTORS Humans Immunobiology immunoglobulin A IMMUNOGLOBULINS Interleukin-5 Interleukins - genetics ISOTOPES LEUKOCYTES LIGHT NUCLEI LIPOTROPIC FACTORS LYMPHOCYTES LYMPHOKINES Lymphokines - genetics Lymphokines, interleukins ( function, expression) MAMMALS MAN MATERIALS Messenger RNA METHIONINE MICE MITOGENS Molecular Sequence Data MOLECULAR STRUCTURE NUCLEI NUCLEIC ACIDS ODD-ODD NUCLEI ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC SULFUR COMPOUNDS PHORBOL ESTERS PHOSPHORUS 32 PHOSPHORUS ISOTOPES PRIMATES Prostatic Secretory Proteins PROTEINS RADIOISOTOPES RECOMBINANT DNA Regulatory factors and their cellular receptors RNA, Messenger - genetics RNA, Messenger - isolation & purification RODENTS SOMATIC CELLS Spleen cells STRUCTURAL CHEMICAL ANALYSIS SULFUR 35 SULFUR ISOTOPES T lymphocytes VERTEBRATES 550201 -- Biochemistry-- Tracer Techniques |
| title | Isolation and Characterization of Lymphokine cDNA Clones Encoding Mouse and Human IgA-Enhancing Factor and Eosinophil Colony-Stimulating Factor Activities: Relationship to Interleukin 5 |
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