Long-Term Physiological Effects of Enhanced O2 Release by Inositol Hexaphosphate-Loaded Erythrocytes

A continuous lysing and resealing procedure with erythrocytes permitted incorporation in these cells of inositol hexaphosphate (InsP6), a strong allosteric effector of Hb. This leads to significant rightward shifts of the HbO2 dissociation curves with in vitro P50 (partial pressure of O2 at 50% Hb s...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1987-10, Vol.84 (19), p.6894-6898
Hauptverfasser:	Teisseire, Bernard, Ropars, Claude, Villeréal, Marie-Christine, Nicolau, Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Blood flow Blood plasma Blood transfusion Carbon Dioxide - blood Cardiac output determination Electrolytes Erythrocytes Erythrocytes - drug effects Erythrocytes - physiology Fundamental and applied biological sciences. Psychology Humans Interactions. Associations Intermolecular phenomena Kinetics Life span Molecular biophysics Oxygen - blood Oxyhemoglobins - metabolism Partial Pressure Phytic Acid - blood Phytic Acid - pharmacology Piglets Swine Washing
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