Ca2+-mobilizing Actions of Platelet-Derived Growth Factor Differ from Those of Bombesin and Vasopressin in Swiss 3T3 Mouse Cells

Addition of the mitogenic peptides bombesin and vasopressin to quiescent Swiss 3T3 mouse cells increased the cytosolic Ca2+ concentration without any measurable delay. In contrast, there was a significant lag period (16 ± 1.2 s) before platelet-derived growth factor (PDGF) increased cytosolic Ca2+ c...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1987-08, Vol.84 (16), p.5768-5772
Hauptverfasser:	Lopez-Rivas, Abelardo, Mendoza, Stanley A., Nånberg, Eewa, Sinnett-Smith, James, Rozengurt, Enrique
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 cells Animals Biological and medical sciences Bombesin - pharmacology Calcium - metabolism Cell growth Cell Line Cell physiology Cells Cultured cells DNA Replication - drug effects Fibroblasts - drug effects Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Humans Inositol phosphates Inositols Kinetics Mice Mitogens Molecular and cellular biology Phorbol esters Phorbol Esters - pharmacology Phosphatidylinositols - metabolism Platelet-Derived Growth Factor - pharmacology Responses to growth factors, tumor promotors, other factors Swine Swiss 3T3 cells Vasopressins - pharmacology
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