Harvey ras Genes Transform without Mutant Codons, Apparently Activated by Truncation of a 5′ Exon (Exon --1)

The hypothesis is tested that the ras gene of Harvey sarcoma virus (Ha-SV) and the proto-ras DNAs from certain tumor cells derive transforming function from specific codons in which they differ from normal proto-ras genes. Molecularly cloned Harvey proviral vectors carrying viral ras, normal rat pro...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1986-04, Vol.83 (8), p.2340-2344
Hauptverfasser:	Cichutek, Klaus, Duesberg, Peter H.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 cells Animals Base Sequence Biological and medical sciences Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cloning, Molecular Codon Codons DNA Embryonic cells Exons Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes Genetic mutation Mice Molecular and cellular biology Mutation Oncogene Proteins, Viral - genetics Oncogenes Proto-Oncogene Proteins - genetics Proto-Oncogenes ras genes Rats Truncation Viruses
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