The Primary Structure of Rat Parathymosin
Parathymosin has been isolated from rat thymus and from rat liver. Its primary structure is reported as follows: AcSer-Lys-Ser-Glu-Val-Glu-Ala-Ala-Ala-$\overset 10\to{\text{Glu}}$-Leu-Ser-Ala-Lys-Asp-Leu-Lys-Glu-Lys-$\ove rset 20\to{\text{Lys}}$-Asp-Lys-Val-Glu-Glu-Lys-Ala-Gly-Arg-$\ove rset 30\to{\...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1986-03, Vol.83 (5), p.1242-1245 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Komiyama, Tadazumi Pan, Lu-Xing Haritos, A. A. Wideman, Janusz W. Pan, Yu-Ching E. Chang, May Rogers, Irene Horecker, B. L. |
| description | Parathymosin has been isolated from rat thymus and from rat liver. Its primary structure is reported as follows: AcSer-Lys-Ser-Glu-Val-Glu-Ala-Ala-Ala-$\overset 10\to{\text{Glu}}$-Leu-Ser-Ala-Lys-Asp-Leu-Lys-Glu-Lys-$\ove rset 20\to{\text{Lys}}$-Asp-Lys-Val-Glu-Glu-Lys-Ala-Gly-Arg-$\ove rset 30\to{\text{Lys}}$-Glu-Arg-Lys-Lys-Glu-Val-Val-Glu-Glu-Glu-Glu-Asn- Gly-Ala-Glu-Glu-Glu-Glu-Glu-$\overset 50\to{\text{Glu}}$-Thr-Ala-Glu-(Gly3,Asx $_{7}$,Glx14)-Glu-Gly-$\overset 80\to{\text{Pro}}$-Val-Arg-Lys-Arg-Thr-Ala-Glu-Glu-Glu-Asp-Glu-Ala- Asp-Pro-Lys-Arg-Gln-Lys-Thr-$\overset 100\to{\text{Glu}}$-Asn-Gly-Ala-Ser-AlaOH. The blocking group at the NH2 terminus was identified by mass spectrometry as acetyl. Regions homologous to amino acid sequences in prothymosin α were found to be located between residues 14-20, 23-25, 33-39, 41-43, and 83-87 of parathymosin. |
| doi_str_mv | 10.1073/pnas.83.5.1242 |
| format | Article |
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A. ; Wideman, Janusz W. ; Pan, Yu-Ching E. ; Chang, May ; Rogers, Irene ; Horecker, B. L.</creator><creatorcontrib>Komiyama, Tadazumi ; Pan, Lu-Xing ; Haritos, A. A. ; Wideman, Janusz W. ; Pan, Yu-Ching E. ; Chang, May ; Rogers, Irene ; Horecker, B. L.</creatorcontrib><description>Parathymosin has been isolated from rat thymus and from rat liver. Its primary structure is reported as follows: AcSer-Lys-Ser-Glu-Val-Glu-Ala-Ala-Ala-$\overset 10\to{\text{Glu}}$-Leu-Ser-Ala-Lys-Asp-Leu-Lys-Glu-Lys-$\ove rset 20\to{\text{Lys}}$-Asp-Lys-Val-Glu-Glu-Lys-Ala-Gly-Arg-$\ove rset 30\to{\text{Lys}}$-Glu-Arg-Lys-Lys-Glu-Val-Val-Glu-Glu-Glu-Glu-Asn- Gly-Ala-Glu-Glu-Glu-Glu-Glu-$\overset 50\to{\text{Glu}}$-Thr-Ala-Glu-(Gly3,Asx $_{7}$,Glx14)-Glu-Gly-$\overset 80\to{\text{Pro}}$-Val-Arg-Lys-Arg-Thr-Ala-Glu-Glu-Glu-Asp-Glu-Ala- Asp-Pro-Lys-Arg-Gln-Lys-Thr-$\overset 100\to{\text{Glu}}$-Asn-Gly-Ala-Ser-AlaOH. The blocking group at the NH2 terminus was identified by mass spectrometry as acetyl. Regions homologous to amino acid sequences in prothymosin α were found to be located between residues 14-20, 23-25, 33-39, 41-43, and 83-87 of parathymosin.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.83.5.1242</identifier><identifier>PMID: 3456585</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Amino Acid Sequence ; Amino acids ; Analytical, structural and metabolic biochemistry ; Animals ; Biochemistry ; Biological and medical sciences ; Centrifugation ; Chemical composition ; Chromatography, High Pressure Liquid ; Elution ; Fundamental and applied biological sciences. Psychology ; Homogenization ; Hydrolysis ; Liver ; Liver - analysis ; Miscellaneous ; Protein Precursors ; Proteins ; Rats ; Sequence homology ; Thymosin - analogs & derivatives ; Thymus Gland - analysis</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1986-03, Vol.83 (5), p.1242-1245</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-1db04c8e895330b0f570565ba85d42bec4caecbea590397ad37ed32d1c15c1c33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/83/5.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/27201$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/27201$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8615661$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3456585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Komiyama, Tadazumi</creatorcontrib><creatorcontrib>Pan, Lu-Xing</creatorcontrib><creatorcontrib>Haritos, A. A.</creatorcontrib><creatorcontrib>Wideman, Janusz W.</creatorcontrib><creatorcontrib>Pan, Yu-Ching E.</creatorcontrib><creatorcontrib>Chang, May</creatorcontrib><creatorcontrib>Rogers, Irene</creatorcontrib><creatorcontrib>Horecker, B. L.</creatorcontrib><title>The Primary Structure of Rat Parathymosin</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Parathymosin has been isolated from rat thymus and from rat liver. Its primary structure is reported as follows: AcSer-Lys-Ser-Glu-Val-Glu-Ala-Ala-Ala-$\overset 10\to{\text{Glu}}$-Leu-Ser-Ala-Lys-Asp-Leu-Lys-Glu-Lys-$\ove rset 20\to{\text{Lys}}$-Asp-Lys-Val-Glu-Glu-Lys-Ala-Gly-Arg-$\ove rset 30\to{\text{Lys}}$-Glu-Arg-Lys-Lys-Glu-Val-Val-Glu-Glu-Glu-Glu-Asn- Gly-Ala-Glu-Glu-Glu-Glu-Glu-$\overset 50\to{\text{Glu}}$-Thr-Ala-Glu-(Gly3,Asx $_{7}$,Glx14)-Glu-Gly-$\overset 80\to{\text{Pro}}$-Val-Arg-Lys-Arg-Thr-Ala-Glu-Glu-Glu-Asp-Glu-Ala- Asp-Pro-Lys-Arg-Gln-Lys-Thr-$\overset 100\to{\text{Glu}}$-Asn-Gly-Ala-Ser-AlaOH. The blocking group at the NH2 terminus was identified by mass spectrometry as acetyl. Regions homologous to amino acid sequences in prothymosin α were found to be located between residues 14-20, 23-25, 33-39, 41-43, and 83-87 of parathymosin.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Centrifugation</subject><subject>Chemical composition</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Elution</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Homogenization</subject><subject>Hydrolysis</subject><subject>Liver</subject><subject>Liver - analysis</subject><subject>Miscellaneous</subject><subject>Protein Precursors</subject><subject>Proteins</subject><subject>Rats</subject><subject>Sequence homology</subject><subject>Thymosin - analogs & derivatives</subject><subject>Thymus Gland - analysis</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtLxDAUhYMoOj62LgShCxFctN68mnThQgZfIDjouA5pmjqVTjsmqei_t8OMZQRXd3G-c8_hIHSMIcEg6OWi0T6RNOEJJoxsoRGGDMcpy2AbjQCIiCUjbA_te_8OABmXsIt2KeMpl3yELqYzG01cNdfuO3oJrjOhczZqy-hZh2iinQ6z73nrq-YQ7ZS69vZofQ_Q6-3NdHwfPz7dPYyvH2PDJA8xLnJgRlqZcUohh5IL6LNyLXnBSG4NM9qa3GqeAc2ELqiwBSUFNpgbbCg9QFerv4sun9vC2CY4XavFqqNqdaX-Kk01U2_tp6KEAse9_3ztd-1HZ31Q88obW9e6sW3nlUgF5YJkPZisQONa750thwwMarmtWm6rJFVcLbftDaebzQZ8PWavn6117Y2uS6cbU_kBkynmabpZcPl-UH9jVNnVdbBfYSPvX7DXT1b6uw-tGwAiCGD6Aw1gosg</recordid><startdate>19860301</startdate><enddate>19860301</enddate><creator>Komiyama, Tadazumi</creator><creator>Pan, Lu-Xing</creator><creator>Haritos, A. A.</creator><creator>Wideman, Janusz W.</creator><creator>Pan, Yu-Ching E.</creator><creator>Chang, May</creator><creator>Rogers, Irene</creator><creator>Horecker, B. L.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19860301</creationdate><title>The Primary Structure of Rat Parathymosin</title><author>Komiyama, Tadazumi ; Pan, Lu-Xing ; Haritos, A. A. ; Wideman, Janusz W. ; Pan, Yu-Ching E. ; Chang, May ; Rogers, Irene ; Horecker, B. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-1db04c8e895330b0f570565ba85d42bec4caecbea590397ad37ed32d1c15c1c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Centrifugation</topic><topic>Chemical composition</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Elution</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Homogenization</topic><topic>Hydrolysis</topic><topic>Liver</topic><topic>Liver - analysis</topic><topic>Miscellaneous</topic><topic>Protein Precursors</topic><topic>Proteins</topic><topic>Rats</topic><topic>Sequence homology</topic><topic>Thymosin - analogs & derivatives</topic><topic>Thymus Gland - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Komiyama, Tadazumi</creatorcontrib><creatorcontrib>Pan, Lu-Xing</creatorcontrib><creatorcontrib>Haritos, A. A.</creatorcontrib><creatorcontrib>Wideman, Janusz W.</creatorcontrib><creatorcontrib>Pan, Yu-Ching E.</creatorcontrib><creatorcontrib>Chang, May</creatorcontrib><creatorcontrib>Rogers, Irene</creatorcontrib><creatorcontrib>Horecker, B. 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L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Primary Structure of Rat Parathymosin</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1986-03-01</date><risdate>1986</risdate><volume>83</volume><issue>5</issue><spage>1242</spage><epage>1245</epage><pages>1242-1245</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Parathymosin has been isolated from rat thymus and from rat liver. Its primary structure is reported as follows: AcSer-Lys-Ser-Glu-Val-Glu-Ala-Ala-Ala-$\overset 10\to{\text{Glu}}$-Leu-Ser-Ala-Lys-Asp-Leu-Lys-Glu-Lys-$\ove rset 20\to{\text{Lys}}$-Asp-Lys-Val-Glu-Glu-Lys-Ala-Gly-Arg-$\ove rset 30\to{\text{Lys}}$-Glu-Arg-Lys-Lys-Glu-Val-Val-Glu-Glu-Glu-Glu-Asn- Gly-Ala-Glu-Glu-Glu-Glu-Glu-$\overset 50\to{\text{Glu}}$-Thr-Ala-Glu-(Gly3,Asx $_{7}$,Glx14)-Glu-Gly-$\overset 80\to{\text{Pro}}$-Val-Arg-Lys-Arg-Thr-Ala-Glu-Glu-Glu-Asp-Glu-Ala- Asp-Pro-Lys-Arg-Gln-Lys-Thr-$\overset 100\to{\text{Glu}}$-Asn-Gly-Ala-Ser-AlaOH. The blocking group at the NH2 terminus was identified by mass spectrometry as acetyl. Regions homologous to amino acid sequences in prothymosin α were found to be located between residues 14-20, 23-25, 33-39, 41-43, and 83-87 of parathymosin.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>3456585</pmid><doi>10.1073/pnas.83.5.1242</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1986-03, Vol.83 (5), p.1242-1245 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Amino Acid Sequence Amino acids Analytical, structural and metabolic biochemistry Animals Biochemistry Biological and medical sciences Centrifugation Chemical composition Chromatography, High Pressure Liquid Elution Fundamental and applied biological sciences. Psychology Homogenization Hydrolysis Liver Liver - analysis Miscellaneous Protein Precursors Proteins Rats Sequence homology Thymosin - analogs & derivatives Thymus Gland - analysis |
| title | The Primary Structure of Rat Parathymosin |
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