Mevinolin, an Inhibitor of Cholesterol Synthesis, Induces mRNA for Low Density Lipoprotein Receptor in Livers of Hamsters and Rabbits

Through the use of a quantitative solution hybridization assay with32P-labeled cDNA probes, we found that mevinolin, an inhibitor of cholesterol synthesis, elevates the level of mRNA for the low density lipoprotein receptor in livers of hamsters and rabbits. In hamsters the maximal effect (3-fold in...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1986-11, Vol.83 (21), p.8370-8374
Hauptverfasser:	Patrick T. S. Ma, Gil, Gregorio, Südhof, Thomas C., Bilheimer, David W., Goldstein, Joseph L., Brown, Michael S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Blood plasma Cholesterol - blood Cholesterols Complementary DNA Cricetinae Female Fundamental and applied biological sciences. Psychology HDL lipoproteins Hydroxymethylglutaryl-CoA Reductase Inhibitors LDL receptors Lipoproteins Lipoproteins - blood Liver Liver - metabolism Lovastatin Male Mesocricetus Messenger RNA Naphthalenes - pharmacology Other biological molecules Rabbits Receptors Receptors, LDL - drug effects Receptors, LDL - genetics RNA RNA, Messenger - biosynthesis Terpenes, steroids. Hormones
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