Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons; Electrophysiological effects of phorbol esters

The vertebrate central nervous system contains very high concentrations of protein kinase C, a calcium-and phospholipid-stimulated phosphorylating enzyme. Phorbol esters, compounds with inflammatory and tumor-promoting properties, bind to and activate this enzyme. To clarify the role of protein kina...

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Veröffentlicht in:	Proc. Natl. Acad. Sci. U.S.A.; (United States) 1985-04, Vol.82 (8), p.2538-2542
Hauptverfasser:	Baraban, J.M, Snyder, S.H, Alger, B.E
Format:	Artikel
Sprache:	eng
Schlagworte:	550601 - Medicine- Unsealed Radionuclides in Diagnostics 551001 - Physiological Systems- Tracer Techniques Action potentials ANIMAL CELLS Animals AUTORADIOGRAPHY BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL EFFECTS BODY BRAIN Caenorhabditis elegans Proteins Calcium CARCINOGENS Carrier Proteins Cell physiology CENTRAL NERVOUS SYSTEM CEREBRO ELECTRIC CONDUCTIVITY ELECTRICAL PROPERTIES Electrophysiology ENCEPHALE ENZYMES ESTERS FISIOLOGIA Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - drug effects Hippocampus - physiology In Vitro Techniques IONIC CONDUCTIVITY LABELLED COMPOUNDS Male membrane conductance Membrane potential Molecular and cellular biology NERVE CELLS NERVOUS SYSTEM Neurons Neurons - physiology Neurotransmission NUTRICION NUTRITION ORGANIC COMPOUNDS ORGANS PHORBOL ESTERS Phorbol Esters - pharmacology Phorbols Phorbols - pharmacology PHOSPHORUS-GROUP TRANSFERASES PHOSPHOTRANSFERASES PHYSICAL PROPERTIES PHYSIOLOGIE PHYSIOLOGY POTASIO POTASSIUM Protein Kinase C Protein Kinases - physiology RADIOLOGY AND NUCLEAR MEDICINE RAT RATA RATS Rats, Inbred Strains RECEPTORS Receptors, Drug Receptors, Immunologic - physiology SOMATIC CELLS TRANSFERASAS TRANSFERASE TRANSFERASES TRITIUM COMPOUNDS
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