Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons; Electrophysiological effects of phorbol esters
The vertebrate central nervous system contains very high concentrations of protein kinase C, a calcium-and phospholipid-stimulated phosphorylating enzyme. Phorbol esters, compounds with inflammatory and tumor-promoting properties, bind to and activate this enzyme. To clarify the role of protein kina...
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| Veröffentlicht in: | Proc. Natl. Acad. Sci. U.S.A.; (United States) 1985-04, Vol.82 (8), p.2538-2542 |
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| creator | Baraban, J.M Snyder, S.H Alger, B.E |
| description | The vertebrate central nervous system contains very high concentrations of protein kinase C, a calcium-and phospholipid-stimulated phosphorylating enzyme. Phorbol esters, compounds with inflammatory and tumor-promoting properties, bind to and activate this enzyme. To clarify the role of protein kinase C in neuronal function, we have localized phorbol ester receptors in the rat hippocampus by autoradiography and examined the electrophysiological effects of phorbol esters on hippocampal pyramidal neurons in vitro. Phorbol esters blocked a calcium-dependent potassium conductance. In addition, phorbol esters blocked the late hyperpolarization elicited by synaptic stimulation even though other synaptic potentials were not affected. The potencies of several phorbol esters in exerting these actions paralleled their affinities for protein kinase C, suggesting that protein kinase C regulates membrane ionic conductance. |
| doi_str_mv | 10.1073/pnas.82.8.2538 |
| format | Article |
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Phorbol esters, compounds with inflammatory and tumor-promoting properties, bind to and activate this enzyme. To clarify the role of protein kinase C in neuronal function, we have localized phorbol ester receptors in the rat hippocampus by autoradiography and examined the electrophysiological effects of phorbol esters on hippocampal pyramidal neurons in vitro. Phorbol esters blocked a calcium-dependent potassium conductance. In addition, phorbol esters blocked the late hyperpolarization elicited by synaptic stimulation even though other synaptic potentials were not affected. The potencies of several phorbol esters in exerting these actions paralleled their affinities for protein kinase C, suggesting that protein kinase C regulates membrane ionic conductance.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.82.8.2538</identifier><identifier>PMID: 3157991</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics ; 551001 - Physiological Systems- Tracer Techniques ; Action potentials ; ANIMAL CELLS ; Animals ; AUTORADIOGRAPHY ; BASIC BIOLOGICAL SCIENCES ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BODY ; BRAIN ; Caenorhabditis elegans Proteins ; Calcium ; CARCINOGENS ; Carrier Proteins ; Cell physiology ; CENTRAL NERVOUS SYSTEM ; CEREBRO ; ELECTRIC CONDUCTIVITY ; ELECTRICAL PROPERTIES ; Electrophysiology ; ENCEPHALE ; ENZYMES ; ESTERS ; FISIOLOGIA ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - physiology ; In Vitro Techniques ; IONIC CONDUCTIVITY ; LABELLED COMPOUNDS ; Male ; membrane conductance ; Membrane potential ; Molecular and cellular biology ; NERVE CELLS ; NERVOUS SYSTEM ; Neurons ; Neurons - physiology ; Neurotransmission ; NUTRICION ; NUTRITION ; ORGANIC COMPOUNDS ; ORGANS ; PHORBOL ESTERS ; Phorbol Esters - pharmacology ; Phorbols ; Phorbols - pharmacology ; PHOSPHORUS-GROUP TRANSFERASES ; PHOSPHOTRANSFERASES ; PHYSICAL PROPERTIES ; PHYSIOLOGIE ; PHYSIOLOGY ; POTASIO ; POTASSIUM ; Protein Kinase C ; Protein Kinases - physiology ; RADIOLOGY AND NUCLEAR MEDICINE ; RAT ; RATA ; RATS ; Rats, Inbred Strains ; RECEPTORS ; Receptors, Drug ; Receptors, Immunologic - physiology ; SOMATIC CELLS ; TRANSFERASAS ; TRANSFERASE ; TRANSFERASES ; TRITIUM COMPOUNDS</subject><ispartof>Proc. Natl. Acad. Sci. U.S.A.; (United States), 1985-04, Vol.82 (8), p.2538-2542</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c628t-46b71e0137f6186fdb949ef30340cab90fe977ad11dda2d97c2f7aed07f80bbc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/82/8.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25135$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25135$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9139497$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3157991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6180956$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Baraban, J.M</creatorcontrib><creatorcontrib>Snyder, S.H</creatorcontrib><creatorcontrib>Alger, B.E</creatorcontrib><creatorcontrib>Johns Hopkins Univ., Baltimore, MD</creatorcontrib><title>Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons; Electrophysiological effects of phorbol esters</title><title>Proc. Natl. Acad. Sci. U.S.A.; (United States)</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The vertebrate central nervous system contains very high concentrations of protein kinase C, a calcium-and phospholipid-stimulated phosphorylating enzyme. Phorbol esters, compounds with inflammatory and tumor-promoting properties, bind to and activate this enzyme. To clarify the role of protein kinase C in neuronal function, we have localized phorbol ester receptors in the rat hippocampus by autoradiography and examined the electrophysiological effects of phorbol esters on hippocampal pyramidal neurons in vitro. Phorbol esters blocked a calcium-dependent potassium conductance. In addition, phorbol esters blocked the late hyperpolarization elicited by synaptic stimulation even though other synaptic potentials were not affected. The potencies of several phorbol esters in exerting these actions paralleled their affinities for protein kinase C, suggesting that protein kinase C regulates membrane ionic conductance.</description><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics</subject><subject>551001 - Physiological Systems- Tracer Techniques</subject><subject>Action potentials</subject><subject>ANIMAL CELLS</subject><subject>Animals</subject><subject>AUTORADIOGRAPHY</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BODY</subject><subject>BRAIN</subject><subject>Caenorhabditis elegans Proteins</subject><subject>Calcium</subject><subject>CARCINOGENS</subject><subject>Carrier Proteins</subject><subject>Cell physiology</subject><subject>CENTRAL NERVOUS SYSTEM</subject><subject>CEREBRO</subject><subject>ELECTRIC CONDUCTIVITY</subject><subject>ELECTRICAL PROPERTIES</subject><subject>Electrophysiology</subject><subject>ENCEPHALE</subject><subject>ENZYMES</subject><subject>ESTERS</subject><subject>FISIOLOGIA</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>In Vitro Techniques</subject><subject>IONIC CONDUCTIVITY</subject><subject>LABELLED COMPOUNDS</subject><subject>Male</subject><subject>membrane conductance</subject><subject>Membrane potential</subject><subject>Molecular and cellular biology</subject><subject>NERVE CELLS</subject><subject>NERVOUS SYSTEM</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>Neurotransmission</subject><subject>NUTRICION</subject><subject>NUTRITION</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANS</subject><subject>PHORBOL ESTERS</subject><subject>Phorbol Esters - pharmacology</subject><subject>Phorbols</subject><subject>Phorbols - pharmacology</subject><subject>PHOSPHORUS-GROUP TRANSFERASES</subject><subject>PHOSPHOTRANSFERASES</subject><subject>PHYSICAL PROPERTIES</subject><subject>PHYSIOLOGIE</subject><subject>PHYSIOLOGY</subject><subject>POTASIO</subject><subject>POTASSIUM</subject><subject>Protein Kinase C</subject><subject>Protein Kinases - physiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Inbred Strains</subject><subject>RECEPTORS</subject><subject>Receptors, Drug</subject><subject>Receptors, Immunologic - physiology</subject><subject>SOMATIC CELLS</subject><subject>TRANSFERASAS</subject><subject>TRANSFERASE</subject><subject>TRANSFERASES</subject><subject>TRITIUM COMPOUNDS</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcurEzEUxgdRrvXq1oUgDCJ3NzXJPJIgLqRcH3BBQe86ZDInba7TZEwyYhf-757SWuvGVcL5fuf5FcVTSpaU8PrV5HVaCrYUS9bW4l6xoETSqmskuV8sCGG8Eg1rHhaPUrojhMhWkIvioqYtl5Iuil-fY8jgfPnNYSEoV2WE9TzqDKl0wTtTmuCH2WTtDZTIbdw0BaO3kx7LaRf11g348zDH4NPr8noEk2OYNrvkwhjWzqAK1mI0lcGW0ybEPmAoZYjpcfHA6jHBk-N7Wdy-u_66-lDdfHr_cfX2pjIdE7lqup5TILTmtqOis0MvGwm2JnVDjO4lsSA51wOlw6DZILlhlmsYCLeC9L2pL4s3h7rT3G9hMOBz1KOaotvquFNBO_Wv4t1GrcMPVUveygbzXxzyQ8pOJeMymA0exuNaCkfCs3YIXR2bxPB9xgXV1iUD46g9hDkp2rCOESYQXB5AE0NKEexpEErU3lS1N1UJpoTam4oJz8_HP-FHF1F_edR1wnvbiGa5dMKQwHvxszL78n_U8zZX_9OVnccxw8-M4LMDeJdyiCeStbRu_4pWB6XXEQe5_SI61jZc1L8BfQHXrw</recordid><startdate>19850401</startdate><enddate>19850401</enddate><creator>Baraban, J.M</creator><creator>Snyder, S.H</creator><creator>Alger, B.E</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19850401</creationdate><title>Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons; Electrophysiological effects of phorbol esters</title><author>Baraban, J.M ; Snyder, S.H ; Alger, B.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c628t-46b71e0137f6186fdb949ef30340cab90fe977ad11dda2d97c2f7aed07f80bbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>550601 - Medicine- Unsealed Radionuclides in Diagnostics</topic><topic>551001 - Physiological Systems- Tracer Techniques</topic><topic>Action potentials</topic><topic>ANIMAL CELLS</topic><topic>Animals</topic><topic>AUTORADIOGRAPHY</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BODY</topic><topic>BRAIN</topic><topic>Caenorhabditis elegans Proteins</topic><topic>Calcium</topic><topic>CARCINOGENS</topic><topic>Carrier Proteins</topic><topic>Cell physiology</topic><topic>CENTRAL NERVOUS SYSTEM</topic><topic>CEREBRO</topic><topic>ELECTRIC CONDUCTIVITY</topic><topic>ELECTRICAL PROPERTIES</topic><topic>Electrophysiology</topic><topic>ENCEPHALE</topic><topic>ENZYMES</topic><topic>ESTERS</topic><topic>FISIOLOGIA</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>In Vitro Techniques</topic><topic>IONIC CONDUCTIVITY</topic><topic>LABELLED COMPOUNDS</topic><topic>Male</topic><topic>membrane conductance</topic><topic>Membrane potential</topic><topic>Molecular and cellular biology</topic><topic>NERVE CELLS</topic><topic>NERVOUS SYSTEM</topic><topic>Neurons</topic><topic>Neurons - physiology</topic><topic>Neurotransmission</topic><topic>NUTRICION</topic><topic>NUTRITION</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANS</topic><topic>PHORBOL ESTERS</topic><topic>Phorbol Esters - pharmacology</topic><topic>Phorbols</topic><topic>Phorbols - pharmacology</topic><topic>PHOSPHORUS-GROUP TRANSFERASES</topic><topic>PHOSPHOTRANSFERASES</topic><topic>PHYSICAL PROPERTIES</topic><topic>PHYSIOLOGIE</topic><topic>PHYSIOLOGY</topic><topic>POTASIO</topic><topic>POTASSIUM</topic><topic>Protein Kinase C</topic><topic>Protein Kinases - physiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Inbred Strains</topic><topic>RECEPTORS</topic><topic>Receptors, Drug</topic><topic>Receptors, Immunologic - physiology</topic><topic>SOMATIC CELLS</topic><topic>TRANSFERASAS</topic><topic>TRANSFERASE</topic><topic>TRANSFERASES</topic><topic>TRITIUM COMPOUNDS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baraban, J.M</creatorcontrib><creatorcontrib>Snyder, S.H</creatorcontrib><creatorcontrib>Alger, B.E</creatorcontrib><creatorcontrib>Johns Hopkins Univ., Baltimore, MD</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proc. Natl. Acad. Sci. U.S.A.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baraban, J.M</au><au>Snyder, S.H</au><au>Alger, B.E</au><aucorp>Johns Hopkins Univ., Baltimore, MD</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons; Electrophysiological effects of phorbol esters</atitle><jtitle>Proc. Natl. Acad. Sci. U.S.A.; (United States)</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1985-04-01</date><risdate>1985</risdate><volume>82</volume><issue>8</issue><spage>2538</spage><epage>2542</epage><pages>2538-2542</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>The vertebrate central nervous system contains very high concentrations of protein kinase C, a calcium-and phospholipid-stimulated phosphorylating enzyme. Phorbol esters, compounds with inflammatory and tumor-promoting properties, bind to and activate this enzyme. To clarify the role of protein kinase C in neuronal function, we have localized phorbol ester receptors in the rat hippocampus by autoradiography and examined the electrophysiological effects of phorbol esters on hippocampal pyramidal neurons in vitro. Phorbol esters blocked a calcium-dependent potassium conductance. In addition, phorbol esters blocked the late hyperpolarization elicited by synaptic stimulation even though other synaptic potentials were not affected. The potencies of several phorbol esters in exerting these actions paralleled their affinities for protein kinase C, suggesting that protein kinase C regulates membrane ionic conductance.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>3157991</pmid><doi>10.1073/pnas.82.8.2538</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proc. Natl. Acad. Sci. U.S.A.; (United States), 1985-04, Vol.82 (8), p.2538-2542 |
| issn | 0027-8424 1091-6490 |
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| recordid | cdi_pnas_primary_82_8_2538_fulltext |
| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 550601 - Medicine- Unsealed Radionuclides in Diagnostics 551001 - Physiological Systems- Tracer Techniques Action potentials ANIMAL CELLS Animals AUTORADIOGRAPHY BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL EFFECTS BODY BRAIN Caenorhabditis elegans Proteins Calcium CARCINOGENS Carrier Proteins Cell physiology CENTRAL NERVOUS SYSTEM CEREBRO ELECTRIC CONDUCTIVITY ELECTRICAL PROPERTIES Electrophysiology ENCEPHALE ENZYMES ESTERS FISIOLOGIA Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - drug effects Hippocampus - physiology In Vitro Techniques IONIC CONDUCTIVITY LABELLED COMPOUNDS Male membrane conductance Membrane potential Molecular and cellular biology NERVE CELLS NERVOUS SYSTEM Neurons Neurons - physiology Neurotransmission NUTRICION NUTRITION ORGANIC COMPOUNDS ORGANS PHORBOL ESTERS Phorbol Esters - pharmacology Phorbols Phorbols - pharmacology PHOSPHORUS-GROUP TRANSFERASES PHOSPHOTRANSFERASES PHYSICAL PROPERTIES PHYSIOLOGIE PHYSIOLOGY POTASIO POTASSIUM Protein Kinase C Protein Kinases - physiology RADIOLOGY AND NUCLEAR MEDICINE RAT RATA RATS Rats, Inbred Strains RECEPTORS Receptors, Drug Receptors, Immunologic - physiology SOMATIC CELLS TRANSFERASAS TRANSFERASE TRANSFERASES TRITIUM COMPOUNDS |
| title | Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons; Electrophysiological effects of phorbol esters |
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