Estradiol 16α -hydroxylation in the Mouse Correlates with Mammary Tumor Incidence and Presence of Murine Mammary Tumor Virus: A Possible Model for the Hormonal Etiology of Breast Cancer in Humans

In this report, we describe our findings on the relationship between estradiol 16α -hydroxylation and mammary tumor incidence. A close correlation between the two has been demonstrated with 16-hydroxylation being elevated in strains with a high incidence of tumors, such as RIII and C3H, and low in s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1985-09, Vol.82 (18), p.6295-6299
Hauptverfasser:	Bradlow, H. Leon, Hershcopf, Richard J., Martucci, Charles P., Fishman, Jack
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Androgens - metabolism Animal tumors. Experimental tumors Animals Aryl Hydrocarbon Hydroxylases Biological and medical sciences Body water Breast cancer Cancer Estradiol - metabolism Estrogens Experimental genital and mammary tumors Inbred strains Mammary Glands, Animal - metabolism Mammary Neoplasms, Experimental - etiology Mammary Neoplasms, Experimental - metabolism Mammary Tumor Virus, Mouse Medical sciences Metabolic diseases Mice Mice, Inbred Strains Oncogenic viruses Progestins - metabolism Prognosis Steroid 16-alpha-Hydroxylase Steroid Hydroxylases - metabolism Tumors Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!