Interaction of Endothelial Cell Growth Factor with Heparin: Characterization by Receptor and Antibody Recognition

Endothelial cell growth factor (ECGF) binds specifically in vitro to membrane receptors present on the surface of several cell types, including murine and human endothelial cells and fibroblasts. Monoclonal antibodies prepared against ECGF that inhibit the mitogenic activity of the growth factor pre...

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Veröffentlicht in:	Proc. Natl. Acad. Sci. U.S.A.; (United States) 1985-09, Vol.82 (18), p.6138-6142
Hauptverfasser:	Schreiber, Alain B., Kenney, John, Kowalski, William J., Friesel, Robert, Mehlman, Tevie, Maciag, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	550601 - Medicine- Unsealed Radionuclides in Diagnostics AMINES ANIMAL CELLS ANIMAL TISSUES ANIMALS ANTIBODIES ANTICOAGULANTS BETA DECAY RADIOISOTOPES Biological and medical sciences BODY CARBOHYDRATES CELL CONSTITUENTS Cell Division - drug effects Cell growth CELL MEMBRANES Cell physiology Cells Cells, Cultured CONFIGURATION INTERACTION CONFORMATIONAL CHANGES CONNECTIVE TISSUE CELLS DAYS LIVING RADIOISOTOPES DRUGS ELECTRON CAPTURE RADIOISOTOPES Endothelial cells Endothelial Growth Factors ENDOTHELIUM Endothelium - metabolism Epitopes FIBROBLASTS Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Growth Substances - immunology Growth Substances - metabolism HEMATOLOGIC AGENTS HEPARIN Heparin - pharmacology Human umbilical vein endothelial cells Humans INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES ISOTOPE APPLICATIONS ISOTOPES MAMMALS MAN MEMBRANES MICE Mitosis Molecular and cellular biology MONOCLONAL ANTIBODIES MUCOPOLYSACCHARIDES NUCLEI ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANIC SULFUR COMPOUNDS PEPTIDES POLYPEPTIDES POLYSACCHARIDES PRIMATES Protein Binding - drug effects Protein Conformation - drug effects PROTEINS RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE RADIONUCLIDE KINETICS RADIORECEPTOR ASSAY Receptors Receptors, Mitogen - metabolism Receptors, Vascular Endothelial Growth Factor Responses to growth factors, tumor promotors, other factors RODENTS SACCHARIDES SOMATIC CELLS TISSUES TRACER TECHNIQUES Ungulates VERTEBRATES
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