Faithful Cell-Cycle Regulation of a Recombinant Mouse Histone H4 Gene is Controlled by Sequences in the 3′-terminal Part of the Gene

We have analyzed the expression of endogenous histone H4 genes and of a newly introduced H4 gene in 21-Tb cells, a mouse mastocytoma cell-cycle mutant. Endogenous H4 mRNAs were less abundant by a factor of 120-180 in G1-arrested than in exponentially multiplying cells. However, H4 transcription rate...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1985-07, Vol.82 (13), p.4389-4393
Hauptverfasser:	Luscher, Bernhard, Stauber, Claudia, Schindler, Richard, Schumperli, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Cell Cycle Cell Line Cell lines Cell Transformation, Neoplastic COS cells Cycloheximide - pharmacology DNA DNA probes DNA, Recombinant - metabolism Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Genes Histones Histones - genetics Mast-Cell Sarcoma - analysis Messenger RNA Mice Molecular and cellular biology Molecular genetics Plasmids RNA RNA, Messenger - metabolism Transcription, Genetic - drug effects
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