Immunochemical Evidence for Induction of the Alcohol-Oxidizing Cytochrome P-450 of Rabbit Liver Microsomes by Diverse Agents: Ethanol, Imidazole, Trichloroethylene, Acetone, Pyrazole, and Isoniazid

Isozyme 3a of rabbit liver microsomal cytochrome P-450, also termed P-450ALC, was previously isolated in this laboratory from animals administered ethanol or imidazole, and the purified cytochrome was shown to function in the reconstituted system as an oxygenase in catalyzing the oxidation of ethano...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1985-06, Vol.82 (12), p.4065-4069
Hauptverfasser:	Koop, Dennis R., Crump, Becky L., Nordblom, Gerald D., Coon, Minor J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetone - pharmacology Analytical, structural and metabolic biochemistry Animals Antibodies Biological and medical sciences Butanols Butanols - metabolism Cellulose nitrate Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - immunology cytochrome P450 Cytochromes Enzyme Induction - drug effects Ethanol Ethanol - pharmacology Fundamental and applied biological sciences. Psychology Hemoproteins Imidazoles Imidazoles - pharmacology Isoenzymes - biosynthesis Isoenzymes - immunology Isoniazid - pharmacology liver Liver microsomes Male Metalloproteins Microsomes Microsomes, Liver - enzymology Oxidation Proteins Pyrazoles Pyrazoles - pharmacology Rabbits Trichloroethylene - pharmacology
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