Construction of Live Vaccines Using Genetically Engineered Poxviruses: Biological Activity of Vaccinia Virus Recombinants Expressing the Hepatitis B Virus Surface Antigen and the Herpes Simplex Virus Glycoprotein D

Potential live vaccines using recombinant vaccinia viruses have been constructed for both hepatitis B and herpes simplex. These recombinant vaccinia viruses express cloned genes of the hepatitis B virus surface antigen (HBsAg) or the glycoprotein D from herpes simplex virus (HSV-gD). The HBsAg synth...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1984-01, Vol.81 (1), p.193-197
Hauptverfasser:	Paoletti, Enzo, Lipinskas, Bernard R., Samsonoff, Carol, Mercer, Susan, Panicali, Dennis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibody Formation Chimera Cloning, Molecular DNA Restriction Enzymes DNA, Recombinant - metabolism Genes Genes, Viral Genetic Engineering - methods Hepatitis antigens Hepatitis B Surface Antigens - genetics Hepatitis B virus Hepatitis B virus - genetics Inoculation Plasmids Rabbits Simplexvirus Simplexvirus - genetics Vaccination Vaccinia Vaccinia virus Vaccinia virus - genetics Viral Envelope Proteins Viral Proteins - genetics Viral Vaccines Viruses
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