Monoclonal Antibodies against the Voltage-Sensitive Na+ Channel from Mammalian Skeletal Muscle

A panel of 13 monoclonal antibodies against the voltage-sensitive Na+ channel of rat skeletal muscle has been characterized. Each of these antibodies reacted with the purified Na+ channel protein in a solid-phase radioimmunoassay. Nine antibodies specifically immunoprecipitated the Na+ channel in a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1984-10, Vol.81 (19), p.6227-6231
Hauptverfasser:	Casadei, Jan M., Gordon, Robert D., Lampson, Lois A., Schotland, Donald L., Barchi, Robert L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal Antigen-Antibody Complex Detergents Epitopes - analysis Fluorescent Antibody Technique Glycoproteins Ion Channels - analysis Ion Channels - metabolism Membrane proteins Mice Mice, Inbred BALB C Monoclonal antibodies Muscles - metabolism Protease inhibitors Radioimmunoassay Rats Sarcolemma Saxitoxin Skeletal muscle Sodium - metabolism
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