Cultured Human Fibroblasts Synthesize and Secrete Thrombospondin and Incorporate It into Extracellular Matrix

Thrombospondin, a major glycoprotein released from α granules of thrombin-stimulated platelets, is a disulfide-bonded trimer of 160-kilodalton subunits. Cultured human foreskin and fetal lung fibroblasts secreted thrombospondin (determined by enzyme-linked immunosorbent assay) into the culture mediu...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1983-02, Vol.80 (4), p.998-1002
Hauptverfasser: Jaffe, Eric A., Ruggiero, Joseph T., Lawrence L. K. Leung, Doyle, Mary Jean, McKeown-Longo, Paula J., Mosher, Deane F.
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Sprache:eng
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