Cycloartenol-derived sterol biosynthesis in the Peronosporales [Phytophthora spp., Pythium spp., Peronophythora litchii, Fungi]
Selected species of the order Peronosporales, which are unable to epoxidize squalene and thus synthesize sterols, are able to metabolize exogenous cycloartenol to lanosterol and in some organisms to fucosterol, ergosterol, and cholesterol. Lanosterol was less effectively utilized but some ergosterol...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1982-06, Vol.79 (12), p.3769-3772 |
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| container_issue | 12 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Warner, Steven A. Eierman, David F. Sovocool, G. Wayne Domnas, Aristotle J. |
| description | Selected species of the order Peronosporales, which are unable to epoxidize squalene and thus synthesize sterols, are able to metabolize exogenous cycloartenol to lanosterol and in some organisms to fucosterol, ergosterol, and cholesterol. Lanosterol was less effectively utilized but some ergosterol and cholesterol were yielded. Fucosterol was very efficiently metabolized by most species to ergosterol, Δ7-ergostenol, Δ5-ergostenol, cholestanol, and cholesterol. Several unknown sterols were observed in most trials. These data suggest a vestigial sterol synthetic pathway derived from cycloartenol, followed by possible isomerization to lanosterol and then to other sterols. |
| doi_str_mv | 10.1073/pnas.79.12.3769 |
| format | Article |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1982-06, Vol.79 (12), p.3769-3772 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pnas_primary_79_12_3769 |
| source | Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Biochemistry Biological Sciences: Botany Chemical composition Cholestanols Cholesterol metabolism Cholesterols Lipids Oomycetes Parasitism Plant biochemistry Sterols |
| title | Cycloartenol-derived sterol biosynthesis in the Peronosporales [Phytophthora spp., Pythium spp., Peronophythora litchii, Fungi] |
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