Dose--Response Curve for Ethylnitrosourea-Induced Specific-Locus Mutations in Mouse Spermatogonia

The extreme mutagenic effectiveness of N-ethyl-N-nitrosourea in the mouse has permitted the accumulation of the most extensive dose--response data yet obtained for chemical induction of specific-locus mutations in spermatogonia. In the lower portion of the curve, below a dose of 100 mg/kg, the data...

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Veröffentlicht in:Proc. Natl. Acad. Sci. U.S.A.; (United States) 1982-06, Vol.79 (11), p.3589-3591
Hauptverfasser: Russell, W. L., Hunsicker, P. R., Raymer, G. D., Steele, M. H., Stelzner, K. F., Thompson, H. M.
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container_end_page 3591
container_issue 11
container_start_page 3589
container_title Proc. Natl. Acad. Sci. U.S.A.; (United States)
container_volume 79
creator Russell, W. L.
Hunsicker, P. R.
Raymer, G. D.
Steele, M. H.
Stelzner, K. F.
Thompson, H. M.
description The extreme mutagenic effectiveness of N-ethyl-N-nitrosourea in the mouse has permitted the accumulation of the most extensive dose--response data yet obtained for chemical induction of specific-locus mutations in spermatogonia. In the lower portion of the curve, below a dose of 100 mg/kg, the data fall statistically significantly below a maximum likelihood fit to a straight line. Independent evidence indicates that, over this dose range, ethylnitrosourea reaches the testis in amounts directly proportional to the injected dose. It is concluded that, despite the mutagenic effectiveness of ethylnitrosourea, the spermatogonia are apparently capable of repairing at least a major part of the mutational damage when the repair process is not swamped by a high dose. This finding is important both in basic studies on the mutagenic action of chemicals in mammals and in risk estimation.
doi_str_mv 10.1073/pnas.79.11.3589
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It is concluded that, despite the mutagenic effectiveness of ethylnitrosourea, the spermatogonia are apparently capable of repairing at least a major part of the mutational damage when the repair process is not swamped by a high dose. 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L.</creatorcontrib><creatorcontrib>Hunsicker, P. R.</creatorcontrib><creatorcontrib>Raymer, G. D.</creatorcontrib><creatorcontrib>Steele, M. H.</creatorcontrib><creatorcontrib>Stelzner, K. F.</creatorcontrib><creatorcontrib>Thompson, H. M.</creatorcontrib><creatorcontrib>Oak Ridge National Lab., TN</creatorcontrib><title>Dose--Response Curve for Ethylnitrosourea-Induced Specific-Locus Mutations in Mouse Spermatogonia</title><title>Proc. Natl. Acad. Sci. U.S.A.; (United States)</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The extreme mutagenic effectiveness of N-ethyl-N-nitrosourea in the mouse has permitted the accumulation of the most extensive dose--response data yet obtained for chemical induction of specific-locus mutations in spermatogonia. In the lower portion of the curve, below a dose of 100 mg/kg, the data fall statistically significantly below a maximum likelihood fit to a straight line. 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L.</au><au>Hunsicker, P. R.</au><au>Raymer, G. D.</au><au>Steele, M. H.</au><au>Stelzner, K. F.</au><au>Thompson, H. M.</au><aucorp>Oak Ridge National Lab., TN</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose--Response Curve for Ethylnitrosourea-Induced Specific-Locus Mutations in Mouse Spermatogonia</atitle><jtitle>Proc. Natl. Acad. Sci. U.S.A.; (United States)</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1982-06-01</date><risdate>1982</risdate><volume>79</volume><issue>11</issue><spage>3589</spage><epage>3591</epage><pages>3589-3591</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>The extreme mutagenic effectiveness of N-ethyl-N-nitrosourea in the mouse has permitted the accumulation of the most extensive dose--response data yet obtained for chemical induction of specific-locus mutations in spermatogonia. In the lower portion of the curve, below a dose of 100 mg/kg, the data fall statistically significantly below a maximum likelihood fit to a straight line. Independent evidence indicates that, over this dose range, ethylnitrosourea reaches the testis in amounts directly proportional to the injected dose. It is concluded that, despite the mutagenic effectiveness of ethylnitrosourea, the spermatogonia are apparently capable of repairing at least a major part of the mutational damage when the repair process is not swamped by a high dose. This finding is important both in basic studies on the mutagenic action of chemicals in mammals and in risk estimation.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>6954505</pmid><doi>10.1073/pnas.79.11.3589</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 0027-8424
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subjects 550400 - Genetics
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
Alleles
Allelism
ANIMALS
BASIC BIOLOGICAL SCIENCES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
Confidence limits
DATA
DNA Repair
Dose response relationship
Dose-Response Relationship, Drug
DOSE-RESPONSE RELATIONSHIPS
Ethylnitrosourea - pharmacology
EXPERIMENTAL DATA
GAMETES
GENE MUTATIONS
Genetic loci
Genetic mutation
GERM CELLS
INFORMATION
Male
MAMMALS
MICE
MUTAGENESIS
Mutation - drug effects
MUTATION FREQUENCY
MUTATIONS
NITROSO COMPOUNDS
Nitrosourea Compounds - pharmacology
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
Radiation dosage
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RECOVERY
REPAIR
RISK ASSESSMENT
RODENTS
SPERMATOGONIA
Spermatogonia - drug effects
Spermatozoa - drug effects
Statistical significance
Testes
VERTEBRATES
title Dose--Response Curve for Ethylnitrosourea-Induced Specific-Locus Mutations in Mouse Spermatogonia
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