Ovalocytic Erythrocytes from Melanesians are Resistant to Invasion by Malaria Parasites in Culture
Ovalocytic erythrocytes from Melanesians in Papua New Guinea have been demonstrated to be resistant to infection by malaria parasites (Plasmodium falciparum) in culture by using a double-label fluorescence assay of merozoite invasion. That merozoites do not bind irreversibly to ovalocytes has been d...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1981-09, Vol.78 (9), p.5829-5832 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Kidson, Chev Lamont, Gretel Saul, Allan Nurse, George T. |
| description | Ovalocytic erythrocytes from Melanesians in Papua New Guinea have been demonstrated to be resistant to infection by malaria parasites (Plasmodium falciparum) in culture by using a double-label fluorescence assay of merozoite invasion. That merozoites do not bind irreversibly to ovalocytes has been demonstrated by an assay that measures competition between ovalocytes and normocytes. Analysis of behavior on thermal deformation has demonstrated that ovalocytes are more more thermostable than normocytes, suggesting that there is a major difference in cytoskeletal structure. These findings with P. falciparum and epidemiological data demonstrating clinical resistance to P. vivax and P. malariae suggest that the membrane alterations(s) in these ovalocytes affect(s) invasion step(s) common to all three species of malaria parasite. |
| doi_str_mv | 10.1073/pnas.78.9.5829 |
| format | Article |
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That merozoites do not bind irreversibly to ovalocytes has been demonstrated by an assay that measures competition between ovalocytes and normocytes. Analysis of behavior on thermal deformation has demonstrated that ovalocytes are more more thermostable than normocytes, suggesting that there is a major difference in cytoskeletal structure. These findings with P. falciparum and epidemiological data demonstrating clinical resistance to P. vivax and P. malariae suggest that the membrane alterations(s) in these ovalocytes affect(s) invasion step(s) common to all three species of malaria parasite.</description><subject>Animals</subject><subject>Asian Continental Ancestry Group</subject><subject>Biological competition</subject><subject>Erythrocyte invasion</subject><subject>Erythrocyte membrane</subject><subject>Erythrocytes</subject><subject>Erythrocytes, Abnormal - parasitology</subject><subject>Erythrocytes, Abnormal - ultrastructure</subject><subject>ethnic groups</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>infection</subject><subject>Infections</subject><subject>Malaria</subject><subject>Malaria - blood</subject><subject>man</subject><subject>membranes</subject><subject>Merozoites</subject><subject>Papua New Guinea</subject><subject>Parasites</subject><subject>Parasitism</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - growth & development</subject><subject>Polynesian culture</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU2LFDEUDKKs4-rVgyDk5K3bfHUnffAgw6oLu6yInsPrdNrN0pOMSXpw_r1pZhxHEDzlJVX1Xr0UQi8pqSmR_O3WQ6qlqru6Uax7hFaUdLRqRUceoxUhTFZKMPEUPUvpgRDSNYpcoAtJWNcIuUL93Q6mYPbZGXwV9_k-Lheb8BjDBt_aCbxNDnzCEC3-UuqUwWecA772O0gueNzv8S1MEB3gzxDL26J3Hq_nKc_RPkdPRpiSfXE8L9G3D1df15-qm7uP1-v3N5UpznMFVFnZAxnbsWFSNG1PBzO2hsLIpTJAy04SlByMGiiQUvOWqF5BS4BxMfBL9O7Qdzv3GzsY63OESW-j20Dc6wBO_414d6-_h53mQikpi_7NUR_Dj9mmrDcuGTstXxDmpCWXnDaE_ZdIGy4EYaIQ6wPRxJBStOPJDCV6SU8v6WmpdKeX9Irg9fkKJ_oxrrPJi-6E_tbrcZ6mbH_ms0b_JBb81QF_SDnEP7Zo0zL-C1nVuVA</recordid><startdate>19810901</startdate><enddate>19810901</enddate><creator>Kidson, Chev</creator><creator>Lamont, Gretel</creator><creator>Saul, Allan</creator><creator>Nurse, George T.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7N</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19810901</creationdate><title>Ovalocytic Erythrocytes from Melanesians are Resistant to Invasion by Malaria Parasites in Culture</title><author>Kidson, Chev ; Lamont, Gretel ; Saul, Allan ; Nurse, George T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c582t-a18e7ba0f6f527456b1dcf6c1af378ca16497a87dc8d1a097a3608b8a60a234d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Asian Continental Ancestry Group</topic><topic>Biological competition</topic><topic>Erythrocyte invasion</topic><topic>Erythrocyte membrane</topic><topic>Erythrocytes</topic><topic>Erythrocytes, Abnormal - parasitology</topic><topic>Erythrocytes, Abnormal - ultrastructure</topic><topic>ethnic groups</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>infection</topic><topic>Infections</topic><topic>Malaria</topic><topic>Malaria - blood</topic><topic>man</topic><topic>membranes</topic><topic>Merozoites</topic><topic>Papua New Guinea</topic><topic>Parasites</topic><topic>Parasitism</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - growth & development</topic><topic>Polynesian culture</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kidson, Chev</creatorcontrib><creatorcontrib>Lamont, Gretel</creatorcontrib><creatorcontrib>Saul, Allan</creatorcontrib><creatorcontrib>Nurse, George T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kidson, Chev</au><au>Lamont, Gretel</au><au>Saul, Allan</au><au>Nurse, George T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ovalocytic Erythrocytes from Melanesians are Resistant to Invasion by Malaria Parasites in Culture</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1981-09-01</date><risdate>1981</risdate><volume>78</volume><issue>9</issue><spage>5829</spage><epage>5832</epage><pages>5829-5832</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Ovalocytic erythrocytes from Melanesians in Papua New Guinea have been demonstrated to be resistant to infection by malaria parasites (Plasmodium falciparum) in culture by using a double-label fluorescence assay of merozoite invasion. That merozoites do not bind irreversibly to ovalocytes has been demonstrated by an assay that measures competition between ovalocytes and normocytes. Analysis of behavior on thermal deformation has demonstrated that ovalocytes are more more thermostable than normocytes, suggesting that there is a major difference in cytoskeletal structure. These findings with P. falciparum and epidemiological data demonstrating clinical resistance to P. vivax and P. malariae suggest that the membrane alterations(s) in these ovalocytes affect(s) invasion step(s) common to all three species of malaria parasite.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>7029547</pmid><doi>10.1073/pnas.78.9.5829</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1981-09, Vol.78 (9), p.5829-5832 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Asian Continental Ancestry Group Biological competition Erythrocyte invasion Erythrocyte membrane Erythrocytes Erythrocytes, Abnormal - parasitology Erythrocytes, Abnormal - ultrastructure ethnic groups Humans Immunity, Innate infection Infections Malaria Malaria - blood man membranes Merozoites Papua New Guinea Parasites Parasitism Plasmodium falciparum Plasmodium falciparum - growth & development Polynesian culture |
| title | Ovalocytic Erythrocytes from Melanesians are Resistant to Invasion by Malaria Parasites in Culture |
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