RNA Splicing Mutation in an Aberrantly Rearranged Immunoglobulin λ I Gene

The mouse cell line MOPC 315 is an IgA (λ II)-producing myeloma. We have studied a derivative of MOPC 315 that secretes normal λ II chains but no heavy chain. This derivative, MOPC 315-26, was found to contain a rearranged λ I gene in addition to a rearranged λ II gene. The rearranged λ I gene was c...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1981-11, Vol.78 (11), p.7019-7023
Hauptverfasser:	Hozumi, Nobumichi, Wu, Gillian E., Murialdo, Helios, Roberts, Linda, Vetter, Dan, Fife, Wendy L., Whiteley, Mary, Sadowski, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals B lymphocytes Bacteriophages Base Sequence Cell Line Cell lines Cloning, Molecular DNA DNA Restriction Enzymes Enzymes Escherichia coli - genetics Gels Genes Genetic mutation Immunoglobulin A - genetics Mice Mutation Nucleotide sequences Plasmacytoma Recombination, Genetic RNA - genetics RNA splicing
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