Nicotinic Acetylcholine Receptor: Evidence for a Functionally Distinct Receptor on Human Lymphocytes
The presence of three distinct cholinergic receptors on human lymphocytes was suggested by the effects of carbamoylcholine on lymphocyte proliferation in vitro. The cells responded to both 0.1 nM and 1 μ M carbamoylcholine by increased proliferation which was blocked by the muscarinic antagonist atr...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1979-09, Vol.76 (9), p.4632-4635 |
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| container_issue | 9 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 76 |
| creator | Richman, David P. Barry G. W. Arnason |
| description | The presence of three distinct cholinergic receptors on human lymphocytes was suggested by the effects of carbamoylcholine on lymphocyte proliferation in vitro. The cells responded to both 0.1 nM and 1 μ M carbamoylcholine by increased proliferation which was blocked by the muscarinic antagonist atropine. This effect occurred in both mitogen-stimulated cells (maximum effect at 24 hr) and nonstimulated cells (maximum effect at 72 hr). In contrast, 1-10 nM carbamoylcholine produced diminished in vitro proliferation, an effect which was blocked by the nicotinic antagonists α -bungarotoxin and d-tubocurarine. |
| doi_str_mv | 10.1073/pnas.76.9.4632 |
| format | Article |
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W. Arnason</creator><creatorcontrib>Richman, David P. ; Barry G. W. Arnason</creatorcontrib><description>The presence of three distinct cholinergic receptors on human lymphocytes was suggested by the effects of carbamoylcholine on lymphocyte proliferation in vitro. The cells responded to both 0.1 nM and 1 μ M carbamoylcholine by increased proliferation which was blocked by the muscarinic antagonist atropine. This effect occurred in both mitogen-stimulated cells (maximum effect at 24 hr) and nonstimulated cells (maximum effect at 72 hr). In contrast, 1-10 nM carbamoylcholine produced diminished in vitro proliferation, an effect which was blocked by the nicotinic antagonists α -bungarotoxin and d-tubocurarine.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.76.9.4632</identifier><identifier>PMID: 291991</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Atropine ; Carbachol - pharmacology ; Cell Division - drug effects ; Cell growth ; Cholinergics ; Dose-Response Relationship, Drug ; Humans ; Ligands ; Lymphocyte Activation - drug effects ; Lymphocytes ; Lymphocytes - cytology ; Lymphocytes - metabolism ; Muscarinic receptors ; Myasthenia gravis ; Myasthenia Gravis - immunology ; Nicotinic antagonists ; Nicotinic receptors ; Parasympatholytics - pharmacology ; Receptors ; Receptors, Cholinergic - metabolism ; Receptors, Nicotinic - metabolism</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1979-09, Vol.76 (9), p.4632-4635</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-9a3387a5cfdb8a3ab39d9bcf6879ffd366d371d6a2e67b0668f8987219e56ce23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/76/9.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/70144$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/70144$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/291991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Richman, David P.</creatorcontrib><creatorcontrib>Barry G. W. Arnason</creatorcontrib><title>Nicotinic Acetylcholine Receptor: Evidence for a Functionally Distinct Receptor on Human Lymphocytes</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The presence of three distinct cholinergic receptors on human lymphocytes was suggested by the effects of carbamoylcholine on lymphocyte proliferation in vitro. The cells responded to both 0.1 nM and 1 μ M carbamoylcholine by increased proliferation which was blocked by the muscarinic antagonist atropine. This effect occurred in both mitogen-stimulated cells (maximum effect at 24 hr) and nonstimulated cells (maximum effect at 72 hr). In contrast, 1-10 nM carbamoylcholine produced diminished in vitro proliferation, an effect which was blocked by the nicotinic antagonists α -bungarotoxin and d-tubocurarine.</description><subject>Atropine</subject><subject>Carbachol - pharmacology</subject><subject>Cell Division - drug effects</subject><subject>Cell growth</subject><subject>Cholinergics</subject><subject>Dose-Response Relationship, Drug</subject><subject>Humans</subject><subject>Ligands</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocytes</subject><subject>Lymphocytes - cytology</subject><subject>Lymphocytes - metabolism</subject><subject>Muscarinic receptors</subject><subject>Myasthenia gravis</subject><subject>Myasthenia Gravis - immunology</subject><subject>Nicotinic antagonists</subject><subject>Nicotinic receptors</subject><subject>Parasympatholytics - pharmacology</subject><subject>Receptors</subject><subject>Receptors, Cholinergic - metabolism</subject><subject>Receptors, Nicotinic - metabolism</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2P1CAAR4nxa1y9ejCacNpbKxTKh4mHzbrrmkw0MXomlILDhkItdGP_ezuZcVwvnjj83gOSB8BLjGqMOHk7Rp1rzmpZU0aaB2CDkcQVoxI9BBuEGl4J2tCn4FnOtwgh2Qr0BDxuJJYSb0D_2ZtUfPQGXhhblmB2Kfho4Vdr7FjS9A5e3fneRmOhSxPU8HqOpvgUdQgL_ODzKptywmGK8GYedITbZRh3ySzF5ufgkdMh2xfH8wx8v776dnlTbb98_HR5sa0MbdtSSU2I4Lo1ru-EJrojspedcUxw6VxPGOsJxz3TjWW8Q4wJJ6TgDZa2ZcY25Ay8P9w7zt1ge2NjmXRQ4-QHPS0qaa_-XaLfqR_pTlGMGSGrf370p_RztrmowWdjQ9DRpjkrTjmjnIoVrA-gmVLOk3WnNzBS-ypqX0VxpqTaV1mF1_d_dsIPGdb5zXHea3_G-_r5_3bl5hCK_VVW8NUBvM1rjL8kwpSS32lArD8</recordid><startdate>19790901</startdate><enddate>19790901</enddate><creator>Richman, David P.</creator><creator>Barry G. W. Arnason</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19790901</creationdate><title>Nicotinic Acetylcholine Receptor: Evidence for a Functionally Distinct Receptor on Human Lymphocytes</title><author>Richman, David P. ; Barry G. W. Arnason</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-9a3387a5cfdb8a3ab39d9bcf6879ffd366d371d6a2e67b0668f8987219e56ce23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Atropine</topic><topic>Carbachol - pharmacology</topic><topic>Cell Division - drug effects</topic><topic>Cell growth</topic><topic>Cholinergics</topic><topic>Dose-Response Relationship, Drug</topic><topic>Humans</topic><topic>Ligands</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphocytes</topic><topic>Lymphocytes - cytology</topic><topic>Lymphocytes - metabolism</topic><topic>Muscarinic receptors</topic><topic>Myasthenia gravis</topic><topic>Myasthenia Gravis - immunology</topic><topic>Nicotinic antagonists</topic><topic>Nicotinic receptors</topic><topic>Parasympatholytics - pharmacology</topic><topic>Receptors</topic><topic>Receptors, Cholinergic - metabolism</topic><topic>Receptors, Nicotinic - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Richman, David P.</creatorcontrib><creatorcontrib>Barry G. W. Arnason</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Richman, David P.</au><au>Barry G. W. Arnason</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nicotinic Acetylcholine Receptor: Evidence for a Functionally Distinct Receptor on Human Lymphocytes</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1979-09-01</date><risdate>1979</risdate><volume>76</volume><issue>9</issue><spage>4632</spage><epage>4635</epage><pages>4632-4635</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>The presence of three distinct cholinergic receptors on human lymphocytes was suggested by the effects of carbamoylcholine on lymphocyte proliferation in vitro. The cells responded to both 0.1 nM and 1 μ M carbamoylcholine by increased proliferation which was blocked by the muscarinic antagonist atropine. This effect occurred in both mitogen-stimulated cells (maximum effect at 24 hr) and nonstimulated cells (maximum effect at 72 hr). In contrast, 1-10 nM carbamoylcholine produced diminished in vitro proliferation, an effect which was blocked by the nicotinic antagonists α -bungarotoxin and d-tubocurarine.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>291991</pmid><doi>10.1073/pnas.76.9.4632</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1979-09, Vol.76 (9), p.4632-4635 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Atropine Carbachol - pharmacology Cell Division - drug effects Cell growth Cholinergics Dose-Response Relationship, Drug Humans Ligands Lymphocyte Activation - drug effects Lymphocytes Lymphocytes - cytology Lymphocytes - metabolism Muscarinic receptors Myasthenia gravis Myasthenia Gravis - immunology Nicotinic antagonists Nicotinic receptors Parasympatholytics - pharmacology Receptors Receptors, Cholinergic - metabolism Receptors, Nicotinic - metabolism |
| title | Nicotinic Acetylcholine Receptor: Evidence for a Functionally Distinct Receptor on Human Lymphocytes |
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