T Lymphocyte Response to H-2 Mutants: Cytotoxic Effectors are Ly-1+2
The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2Kbaand H-2Ddaalloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1979-07, Vol.76 (7), p.3455-3459 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Wettstein, Peter J. Bailey, Donald W. Mobraaten, Larry E. Klein, Jan Frelinger, Jeffrey A. |
| description | The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2Kbaand H-2Ddaalloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis demonstrated that the mutant-specific T cells were Ly-1+2+. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1+2+, demonstrated that Ly-1+2+T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of responsive T cells. |
| doi_str_mv | 10.1073/pnas.76.7.3455 |
| format | Article |
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Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2Kbaand H-2Ddaalloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis demonstrated that the mutant-specific T cells were Ly-1+2+. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1+2+, demonstrated that Ly-1+2+T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of responsive T cells.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.76.7.3455</identifier><identifier>PMID: 158760</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Alleles ; Animals ; Antigens ; Cytolysis ; Cytotoxicity ; Cytotoxicity, Immunologic ; Genes, MHC Class II ; H-2 Antigens - genetics ; Isoantigens ; Isoantigens - genetics ; Lymphocyte Activation ; Lymphocyte Culture Test, Mixed ; Lymphocytes ; Mice ; Mixed lymphocyte culture test ; Mutation ; Phenotype ; Phenotypes ; Spleen cells ; T lymphocytes ; T-Lymphocytes - immunology</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1979-07, Vol.76 (7), p.3455-3459</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3705-e950122544290f638fe7830028361de1c0571929d621888c08a1a6ba12113a493</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/76/7.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/70010$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/70010$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/158760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wettstein, Peter J.</creatorcontrib><creatorcontrib>Bailey, Donald W.</creatorcontrib><creatorcontrib>Mobraaten, Larry E.</creatorcontrib><creatorcontrib>Klein, Jan</creatorcontrib><creatorcontrib>Frelinger, Jeffrey A.</creatorcontrib><title>T Lymphocyte Response to H-2 Mutants: Cytotoxic Effectors are Ly-1+2</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2Kbaand H-2Ddaalloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis demonstrated that the mutant-specific T cells were Ly-1+2+. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1+2+, demonstrated that Ly-1+2+T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of responsive T cells.</description><subject>Alleles</subject><subject>Animals</subject><subject>Antigens</subject><subject>Cytolysis</subject><subject>Cytotoxicity</subject><subject>Cytotoxicity, Immunologic</subject><subject>Genes, MHC Class II</subject><subject>H-2 Antigens - genetics</subject><subject>Isoantigens</subject><subject>Isoantigens - genetics</subject><subject>Lymphocyte Activation</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>Lymphocytes</subject><subject>Mice</subject><subject>Mixed lymphocyte culture test</subject><subject>Mutation</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Spleen cells</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1P3DAURa0KWgbKlkVVpKzYoKTv2Y7tILFAw1elqSpVdG0Zj1OCMnGIHcT8ezzMtMCmKy_uOfbVNSEHCAWCZN_6zoRCikIWjJflBzJBqDAXvIItMgGgMlec8h2yG8I9AFSlgk_kI5ZKCpiQ85tstlz0d94uo8t-udD7Lrgs-uw6p9mPMZouhpNsuow--qfGZhd17Wz0Q8jM4JKb4zH9TLZr0wa3vzn3yO_Li5vpdT77efV9ejbLLZNQ5q4qASktOacV1IKp2knFUkXFBM4dWiglVrSaC4pKKQvKoBG3BikiM7xie-R0fW8_3i7c3LouDqbV_dAszLDU3jT6fdI1d_qPf9RMMcV58o82_uAfRheiXjTBurY1nfNj0JJLxgVCAos1aAcfwuDqf28g6NXqerW6lkJLvVo9CV_fNnvFX2ZO8eEmXml_w7f60f9yXY9tG91TTOCXNXgf0h-8kgCp9TMGFpu7</recordid><startdate>19790701</startdate><enddate>19790701</enddate><creator>Wettstein, Peter J.</creator><creator>Bailey, Donald W.</creator><creator>Mobraaten, Larry E.</creator><creator>Klein, Jan</creator><creator>Frelinger, Jeffrey A.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19790701</creationdate><title>T Lymphocyte Response to H-2 Mutants: Cytotoxic Effectors are Ly-1+2</title><author>Wettstein, Peter J. ; Bailey, Donald W. ; Mobraaten, Larry E. ; Klein, Jan ; Frelinger, Jeffrey A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3705-e950122544290f638fe7830028361de1c0571929d621888c08a1a6ba12113a493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>Antigens</topic><topic>Cytolysis</topic><topic>Cytotoxicity</topic><topic>Cytotoxicity, Immunologic</topic><topic>Genes, MHC Class II</topic><topic>H-2 Antigens - genetics</topic><topic>Isoantigens</topic><topic>Isoantigens - genetics</topic><topic>Lymphocyte Activation</topic><topic>Lymphocyte Culture Test, Mixed</topic><topic>Lymphocytes</topic><topic>Mice</topic><topic>Mixed lymphocyte culture test</topic><topic>Mutation</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Spleen cells</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wettstein, Peter J.</creatorcontrib><creatorcontrib>Bailey, Donald W.</creatorcontrib><creatorcontrib>Mobraaten, Larry E.</creatorcontrib><creatorcontrib>Klein, Jan</creatorcontrib><creatorcontrib>Frelinger, Jeffrey A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wettstein, Peter J.</au><au>Bailey, Donald W.</au><au>Mobraaten, Larry E.</au><au>Klein, Jan</au><au>Frelinger, Jeffrey A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T Lymphocyte Response to H-2 Mutants: Cytotoxic Effectors are Ly-1+2</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1979-07-01</date><risdate>1979</risdate><volume>76</volume><issue>7</issue><spage>3455</spage><epage>3459</epage><pages>3455-3459</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2Kbaand H-2Ddaalloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis demonstrated that the mutant-specific T cells were Ly-1+2+. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1+2+, demonstrated that Ly-1+2+T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of responsive T cells.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>158760</pmid><doi>10.1073/pnas.76.7.3455</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1979-07, Vol.76 (7), p.3455-3459 |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Alleles Animals Antigens Cytolysis Cytotoxicity Cytotoxicity, Immunologic Genes, MHC Class II H-2 Antigens - genetics Isoantigens Isoantigens - genetics Lymphocyte Activation Lymphocyte Culture Test, Mixed Lymphocytes Mice Mixed lymphocyte culture test Mutation Phenotype Phenotypes Spleen cells T lymphocytes T-Lymphocytes - immunology |
| title | T Lymphocyte Response to H-2 Mutants: Cytotoxic Effectors are Ly-1+2 |
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