Mouse Cytolytic T Lymphocytes Induced by Xenogeneic Rat Stimulator Cells Exhibit Specificity for H-2 Complex Alloantigens
When mouse spleen cells were stimulated with irradiated xenogeneic, allogeneic, or trinitrophenyl-modified syngeneic lymphoid cells, the strongest cytolytic response was induced by alloantigens. Mouse cytolytic T lymphocytes generated to rat lymphoid cells demonstrated specificity for the immunizing...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1977-10, Vol.74 (10), p.4572-4576 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Burakoff, Steven J. Ratnofsky, Sheldon E. Benacerraf, Baruj |
| description | When mouse spleen cells were stimulated with irradiated xenogeneic, allogeneic, or trinitrophenyl-modified syngeneic lymphoid cells, the strongest cytolytic response was induced by alloantigens. Mouse cytolytic T lymphocytes generated to rat lymphoid cells demonstrated specificity for the immunizing rat strain, but extensive lysis of allogeneic target cells from certain mouse strains was also observed. Cold target inhibition studies indicated that separate clones of xenoantigen-induced cytolytic T lymphocytes lysed each of the allogeneic murine targets. [3H]Thymidine suicide of the effector cells generated to the rat stimulators revealed that only some of all potentially reactive mouse cytolytic T lymphocyte precursors with specificity for a given allogeneic target are activated by the stimulation with rat cells. This evidence that xenoantigens induce alloreactive cytolytic T lymphocytes is discussed in light of our proposal that the cytolytic T lymphocyte receptor repertoire is directed at variants of autologous major histocompatibility complex antigens. |
| doi_str_mv | 10.1073/pnas.74.10.4572 |
| format | Article |
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Mouse cytolytic T lymphocytes generated to rat lymphoid cells demonstrated specificity for the immunizing rat strain, but extensive lysis of allogeneic target cells from certain mouse strains was also observed. Cold target inhibition studies indicated that separate clones of xenoantigen-induced cytolytic T lymphocytes lysed each of the allogeneic murine targets. [3H]Thymidine suicide of the effector cells generated to the rat stimulators revealed that only some of all potentially reactive mouse cytolytic T lymphocyte precursors with specificity for a given allogeneic target are activated by the stimulation with rat cells. This evidence that xenoantigens induce alloreactive cytolytic T lymphocytes is discussed in light of our proposal that the cytolytic T lymphocyte receptor repertoire is directed at variants of autologous major histocompatibility complex antigens.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.74.10.4572</identifier><identifier>PMID: 73180</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Antibody Specificity ; Antigens ; B lymphocytes ; Blasts ; Cells, Cultured ; Chromium Radioisotopes ; Clone Cells ; Cross Reactions ; Cytotoxicity, Immunologic ; Epitopes ; H-2 Antigens ; Heterophile antigens ; Isoantigens ; Lymph nodes ; Lymphocytes ; Mice ; Mice, Inbred C57BL - immunology ; Mice, Inbred Strains - immunology ; Rats ; Rats, Inbred Strains - immunology ; Spleen ; Spleen cells ; T lymphocytes ; T-Lymphocytes - immunology ; Thymidine - physiology</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1977-10, Vol.74 (10), p.4572-4576</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-4f321fd848903749ed62a3d7b4555a8ec5cf0418f5a8823ef2974161114626a93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/74/10.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/67784$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/67784$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/73180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burakoff, Steven J.</creatorcontrib><creatorcontrib>Ratnofsky, Sheldon E.</creatorcontrib><creatorcontrib>Benacerraf, Baruj</creatorcontrib><title>Mouse Cytolytic T Lymphocytes Induced by Xenogeneic Rat Stimulator Cells Exhibit Specificity for H-2 Complex Alloantigens</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>When mouse spleen cells were stimulated with irradiated xenogeneic, allogeneic, or trinitrophenyl-modified syngeneic lymphoid cells, the strongest cytolytic response was induced by alloantigens. Mouse cytolytic T lymphocytes generated to rat lymphoid cells demonstrated specificity for the immunizing rat strain, but extensive lysis of allogeneic target cells from certain mouse strains was also observed. Cold target inhibition studies indicated that separate clones of xenoantigen-induced cytolytic T lymphocytes lysed each of the allogeneic murine targets. [3H]Thymidine suicide of the effector cells generated to the rat stimulators revealed that only some of all potentially reactive mouse cytolytic T lymphocyte precursors with specificity for a given allogeneic target are activated by the stimulation with rat cells. This evidence that xenoantigens induce alloreactive cytolytic T lymphocytes is discussed in light of our proposal that the cytolytic T lymphocyte receptor repertoire is directed at variants of autologous major histocompatibility complex antigens.</description><subject>Animals</subject><subject>Antibody Specificity</subject><subject>Antigens</subject><subject>B lymphocytes</subject><subject>Blasts</subject><subject>Cells, Cultured</subject><subject>Chromium Radioisotopes</subject><subject>Clone Cells</subject><subject>Cross Reactions</subject><subject>Cytotoxicity, Immunologic</subject><subject>Epitopes</subject><subject>H-2 Antigens</subject><subject>Heterophile antigens</subject><subject>Isoantigens</subject><subject>Lymph nodes</subject><subject>Lymphocytes</subject><subject>Mice</subject><subject>Mice, Inbred C57BL - immunology</subject><subject>Mice, Inbred Strains - immunology</subject><subject>Rats</subject><subject>Rats, Inbred Strains - immunology</subject><subject>Spleen</subject><subject>Spleen cells</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><subject>Thymidine - physiology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFvFCEYxYmx0W31bKKJ4aSn2cLADHDw0EyqbbLGRGvijbAMdGmYYRwYs_Pfl3E3m3rxRF7e73188AB4g9EaI0Yuh17FNaNZrGnFymdghZHARU0Feg5WCJWs4LSkL8F5jA8IIVFx9AKcMYI5WoH5a5iigc2cgp-T0_AObuZu2AU9JxPhbd9O2rRwO8Nfpg_3pjeZ-a4S_JFcN3mVwggb432E1_ud27psDEY767RLM7TZvSlK2IRu8GYPr7wPqk8uz4mvwJlVPprXx_MC_Px8fdfcFJtvX26bq02haSVSQS0psW055QIRRoVp61KRlm1pVVWKG11piyjmNgteEmNLwSiuMca0LmslyAX4dJg7TNvOtNr0aVReDqPr1DjLoJz81-ndTt6HP5ISLDjP-Q_H_Bh-TyYm2bmo85NVb_LfSUaYQBhVGbw8gHoMMY7Gnu7ASC5VyaUqyeiil6py4t3T1U78326y-_7oLrGT9zT-8b-AtJP3yexTJt8eyIeYCzuhNWOckkf0qrIj</recordid><startdate>19771001</startdate><enddate>19771001</enddate><creator>Burakoff, Steven J.</creator><creator>Ratnofsky, Sheldon E.</creator><creator>Benacerraf, Baruj</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19771001</creationdate><title>Mouse Cytolytic T Lymphocytes Induced by Xenogeneic Rat Stimulator Cells Exhibit Specificity for H-2 Complex Alloantigens</title><author>Burakoff, Steven J. ; Ratnofsky, Sheldon E. ; Benacerraf, Baruj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-4f321fd848903749ed62a3d7b4555a8ec5cf0418f5a8823ef2974161114626a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Antibody Specificity</topic><topic>Antigens</topic><topic>B lymphocytes</topic><topic>Blasts</topic><topic>Cells, Cultured</topic><topic>Chromium Radioisotopes</topic><topic>Clone Cells</topic><topic>Cross Reactions</topic><topic>Cytotoxicity, Immunologic</topic><topic>Epitopes</topic><topic>H-2 Antigens</topic><topic>Heterophile antigens</topic><topic>Isoantigens</topic><topic>Lymph nodes</topic><topic>Lymphocytes</topic><topic>Mice</topic><topic>Mice, Inbred C57BL - immunology</topic><topic>Mice, Inbred Strains - immunology</topic><topic>Rats</topic><topic>Rats, Inbred Strains - immunology</topic><topic>Spleen</topic><topic>Spleen cells</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - immunology</topic><topic>Thymidine - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burakoff, Steven J.</creatorcontrib><creatorcontrib>Ratnofsky, Sheldon E.</creatorcontrib><creatorcontrib>Benacerraf, Baruj</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burakoff, Steven J.</au><au>Ratnofsky, Sheldon E.</au><au>Benacerraf, Baruj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mouse Cytolytic T Lymphocytes Induced by Xenogeneic Rat Stimulator Cells Exhibit Specificity for H-2 Complex Alloantigens</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1977-10-01</date><risdate>1977</risdate><volume>74</volume><issue>10</issue><spage>4572</spage><epage>4576</epage><pages>4572-4576</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>When mouse spleen cells were stimulated with irradiated xenogeneic, allogeneic, or trinitrophenyl-modified syngeneic lymphoid cells, the strongest cytolytic response was induced by alloantigens. Mouse cytolytic T lymphocytes generated to rat lymphoid cells demonstrated specificity for the immunizing rat strain, but extensive lysis of allogeneic target cells from certain mouse strains was also observed. Cold target inhibition studies indicated that separate clones of xenoantigen-induced cytolytic T lymphocytes lysed each of the allogeneic murine targets. [3H]Thymidine suicide of the effector cells generated to the rat stimulators revealed that only some of all potentially reactive mouse cytolytic T lymphocyte precursors with specificity for a given allogeneic target are activated by the stimulation with rat cells. This evidence that xenoantigens induce alloreactive cytolytic T lymphocytes is discussed in light of our proposal that the cytolytic T lymphocyte receptor repertoire is directed at variants of autologous major histocompatibility complex antigens.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>73180</pmid><doi>10.1073/pnas.74.10.4572</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1977-10, Vol.74 (10), p.4572-4576 |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Antibody Specificity Antigens B lymphocytes Blasts Cells, Cultured Chromium Radioisotopes Clone Cells Cross Reactions Cytotoxicity, Immunologic Epitopes H-2 Antigens Heterophile antigens Isoantigens Lymph nodes Lymphocytes Mice Mice, Inbred C57BL - immunology Mice, Inbred Strains - immunology Rats Rats, Inbred Strains - immunology Spleen Spleen cells T lymphocytes T-Lymphocytes - immunology Thymidine - physiology |
| title | Mouse Cytolytic T Lymphocytes Induced by Xenogeneic Rat Stimulator Cells Exhibit Specificity for H-2 Complex Alloantigens |
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