Role of Epithelial Architecture and Intracellular Metabolism in Proline Uptake and Transtubular Reclamation in PRO/Re Mouse Kidney

The homozygous PRO/Re mouse has less than 1% of the very high proline oxidase activity that characterizes normal kidney cortex. In PRO/Re mouse the endogenous proline concentration is eight times normal in plasma and four times normal in kidney cortex cells, but 50 times normal in urine. The integri...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1975-04, Vol.72 (4), p.1431-1435
Hauptverfasser:	Scriver, Charles R., McInnes, Roderick R., Mohyuddin, Fazl
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid metabolism Amino acids Animals Biological Transport Blood plasma Epithelial Cells Epithelium - metabolism Epithelium - ultrastructure Glomerular Filtration Rate Humans Kidney cortex Kidney Cortex - metabolism Kidney Tubules - metabolism Kidneys Kinetics Mice Mice, Inbred Strains Oxidases Oxidation Proline - metabolism Rats Renal clearance Species Specificity Urine
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