Effects of Dialyzable Transfer Factor in Patients with Breast Cancer
Five patients with advanced breast cancer were treated with pooled dialyzable transfer factor from healthy adult donors. The period of treatment ranged from 21 to 310 days, the total dose from 20 to 257 ml. Transfer factor did not elicit inflammatory or hypersensitivity reactions or detectable forma...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1974-06, Vol.71 (6), p.2319-2323 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 71 |
| creator | Oettgen, H. F. Old, L. J. Farrow, J. H. Valentine, F. T. Lawrence, H. S. Thomas, L. |
| description | Five patients with advanced breast cancer were treated with pooled dialyzable transfer factor from healthy adult donors. The period of treatment ranged from 21 to 310 days, the total dose from 20 to 257 ml. Transfer factor did not elicit inflammatory or hypersensitivity reactions or detectable formation of antibody to itself, nor any hematological or biochemical abnormalities or other side effects. Three patients became responsive (by skin test) to tuberculin and/or streptococcal antigens. Marked partial regression of the breast cancer, lasting 6 months, was observed in one patient. |
| doi_str_mv | 10.1073/pnas.71.6.2319 |
| format | Article |
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Marked partial regression of the breast cancer, lasting 6 months, was observed in one patient.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial</subject><subject>Antibodies, Neoplasm</subject><subject>Antibody Formation</subject><subject>Antigens</subject><subject>Antigens, Bacterial</subject><subject>Biological Sciences: Immunology</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - immunology</subject><subject>Breast Neoplasms - therapy</subject><subject>Cancer</subject><subject>Carcinoma - immunology</subject><subject>Carcinoma - therapy</subject><subject>Carcinoma, Intraductal, Noninfiltrating - immunology</subject><subject>Carcinoma, Intraductal, Noninfiltrating - therapy</subject><subject>Cellular immunity</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Immunity, Cellular</subject><subject>Immunity, Maternally-Acquired</subject><subject>Immunization, Passive</subject><subject>Immunotherapy</subject><subject>Leukocytes</subject><subject>Lymphatic Metastasis</subject><subject>Lymphocytes</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Streptococcus - immunology</subject><subject>Transplantation immunology</subject><subject>Tuberculin</subject><subject>Tuberculin Test</subject><subject>Tumors</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkTtPwzAURi0EKuWxMiAhZWJL8CuOMzBAH4BUCYYyWzeuTVOlSbFdoPx6UrVURWLy8J1z79VnhC4ITgjO2M2iBp9kJBEJZSQ_QF2CcxILnuND1MWYZrHklB-jE-9nGOM8lbiDOpwJkQncRf2BtUYHHzU26pdQrb6hqEw0dlB7a1w0BB0aF5V19AKhNHVLfpZhGt07Az5EPai1cWfoyELlzfn2PUWvw8G49xiPnh-eenejWPNUhDgVqQHBKNZ5xiTRRYFlaidUEksZ8KKwONNg09wwC7JIUzEh3HBmSUGoYJqdotvN3MWymJuJbs9xUKmFK-fgVqqBUv1N6nKq3poPxaTknLf-9dZ3zfvS-KDmpdemqqA2zdIrSTmhOBctmGxA7RrvnbG7HQSrde1qXbvKiBJqXXsrXO1ftsO3Pe9tXnu_6c5XdllVwXyFvUH_gm1-uclnvv2XHSAYJ5z9ANnyn4g</recordid><startdate>19740601</startdate><enddate>19740601</enddate><creator>Oettgen, H. F.</creator><creator>Old, L. J.</creator><creator>Farrow, J. H.</creator><creator>Valentine, F. T.</creator><creator>Lawrence, H. S.</creator><creator>Thomas, L.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19740601</creationdate><title>Effects of Dialyzable Transfer Factor in Patients with Breast Cancer</title><author>Oettgen, H. F. ; Old, L. J. ; Farrow, J. H. ; Valentine, F. T. ; Lawrence, H. S. ; Thomas, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-565ea6320c97381cbb085fd281f23a4bbf07caf59e3fa8b556d14e43f1b1263c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial</topic><topic>Antibodies, Neoplasm</topic><topic>Antibody Formation</topic><topic>Antigens</topic><topic>Antigens, Bacterial</topic><topic>Biological Sciences: Immunology</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - immunology</topic><topic>Breast Neoplasms - therapy</topic><topic>Cancer</topic><topic>Carcinoma - immunology</topic><topic>Carcinoma - therapy</topic><topic>Carcinoma, Intraductal, Noninfiltrating - immunology</topic><topic>Carcinoma, Intraductal, Noninfiltrating - therapy</topic><topic>Cellular immunity</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity, Delayed - immunology</topic><topic>Immunity, Cellular</topic><topic>Immunity, Maternally-Acquired</topic><topic>Immunization, Passive</topic><topic>Immunotherapy</topic><topic>Leukocytes</topic><topic>Lymphatic Metastasis</topic><topic>Lymphocytes</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Streptococcus - immunology</topic><topic>Transplantation immunology</topic><topic>Tuberculin</topic><topic>Tuberculin Test</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oettgen, H. F.</creatorcontrib><creatorcontrib>Old, L. J.</creatorcontrib><creatorcontrib>Farrow, J. H.</creatorcontrib><creatorcontrib>Valentine, F. T.</creatorcontrib><creatorcontrib>Lawrence, H. S.</creatorcontrib><creatorcontrib>Thomas, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oettgen, H. F.</au><au>Old, L. J.</au><au>Farrow, J. H.</au><au>Valentine, F. T.</au><au>Lawrence, H. S.</au><au>Thomas, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Dialyzable Transfer Factor in Patients with Breast Cancer</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1974-06-01</date><risdate>1974</risdate><volume>71</volume><issue>6</issue><spage>2319</spage><epage>2323</epage><pages>2319-2323</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Five patients with advanced breast cancer were treated with pooled dialyzable transfer factor from healthy adult donors. The period of treatment ranged from 21 to 310 days, the total dose from 20 to 257 ml. Transfer factor did not elicit inflammatory or hypersensitivity reactions or detectable formation of antibody to itself, nor any hematological or biochemical abnormalities or other side effects. Three patients became responsive (by skin test) to tuberculin and/or streptococcal antigens. Marked partial regression of the breast cancer, lasting 6 months, was observed in one patient.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>4366760</pmid><doi>10.1073/pnas.71.6.2319</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0027-8424 1091-6490 |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Antibodies Antibodies, Bacterial Antibodies, Neoplasm Antibody Formation Antigens Antigens, Bacterial Biological Sciences: Immunology Breast cancer Breast Neoplasms - immunology Breast Neoplasms - therapy Cancer Carcinoma - immunology Carcinoma - therapy Carcinoma, Intraductal, Noninfiltrating - immunology Carcinoma, Intraductal, Noninfiltrating - therapy Cellular immunity Female Humans Hypersensitivity, Delayed - immunology Immunity, Cellular Immunity, Maternally-Acquired Immunization, Passive Immunotherapy Leukocytes Lymphatic Metastasis Lymphocytes Middle Aged Neoplasm Metastasis Streptococcus - immunology Transplantation immunology Tuberculin Tuberculin Test Tumors |
| title | Effects of Dialyzable Transfer Factor in Patients with Breast Cancer |
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