New Method to Prepare N-t-Butoxycarbonyl Derivatives and the Corresponding Sulfur Analogs from di-t-Butyl Dicarbonate or di-t-Butyl Dithiol Dicarbonates and Amino Acids

Di-t-butyl dicarbonate and one of its dithiol analogs, practical methods of preparation for which are given, react with amino-acid esters to form the N-t-butoxycarbonyl (t-BOC) derivatives and the thiol analogs in good yield under mild conditions. The thiol analogs are stable to acidic conditions, w...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1972-03, Vol.69 (3), p.730-732
Hauptverfasser:	Tarbell, D. Stanley, Yamamoto, Yutaka, Pope, Barry M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Esters Evaporators Hydrochlorides Infrared radiation Oxygen Physical Sciences: Chemistry Room temperature Solvents Sulfur Thiols
Online-Zugang:	Volltext
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