Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson’s disease

Lewy bodies (LBs) are intraneuronal inclusions consisting primarily of fibrillized human α-synuclein (hα-Syn) protein, which represent the major pathological hallmark of Parkinson’s disease (PD). Although doubling hα-Syn expression provokes LB pathology in humans, hα-Syn overexpression does not trig...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-02, Vol.113 (7), p.E912-E921
Hauptverfasser:	Fares, Mohamed-Bilal, Maco, Bohumil, Oueslati, Abid, Rockenstein, Edward, Ninkina, Natalia, Buchman, Vladimir L., Masliah, Eliezer, Lashuel, Hilal A.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - genetics alpha-Synuclein - metabolism Animals Biological Sciences Disease Models, Animal Mice Mice, Knockout Neurons - metabolism Parkinson Disease - metabolism PNAS Plus
Online-Zugang:	Volltext
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