Multiplexed autoantigen microarrays identify HLA as a key driver of anti-desmoglein and -non-desmoglein reactivities in pemphigus

Patients with pemphigus vulgaris (PV) harbor antibodies reactive against self-antigens expressed at the surface of keratinocytes, primarily desmoglein (Dsg) 3 and, to a lesser extent, Dsg1. Conventionally, only antibodies targeting these molecules have been thought to contribute to disease pathogene...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-02, Vol.113 (7), p.1859-1864
Hauptverfasser:	Sajda, Thomas, Hazelton, Julian, Patel, Milan, Seiffert-Sinha, Kristina, Steinman, Lawrence, Robinson, William, Haab, Brian B., Sinha, Animesh A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody Specificity Antigens Autoantigens - immunology Biological Sciences Case-Control Studies Desmogleins - immunology Genetics HLA Antigens - immunology Humans Molecules Pathogenesis Pemphigus - immunology Protein Array Analysis Proteins
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