Force-producing ADP state of myosin bound to actin

Molecular motors produce force when they interact with their cellular tracks. For myosin motors, the primary force-generating state has MgADP tightly bound, whereas myosin is strongly bound to actin. We have generated an 8-Å cryoEM reconstruction of this state for myosin V and used molecular dynamic...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-03, Vol.113 (13), p.E1844-E1852
Hauptverfasser:	Wulf, Sarah F., Ropars, Virginie, Fujita-Becker, Setsuko, Oster, Marco, Hofhaus, Goetz, Trabuco, Leonardo G., Pylypenko, Olena, Sweeney, H. Lee, Houdusse, Anne M., Schröder, Rasmus R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - chemistry Actins - metabolism Adenosine Diphosphate - metabolism Binding Sites Biological Sciences Cryoelectron Microscopy Crystallography, X-Ray Humans Life Sciences Models, Molecular Molecular biology Molecular Dynamics Simulation Molecules Myosin Type V - chemistry Myosin Type V - metabolism PNAS Plus Protein Conformation Proteins
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