Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8

Toll-like receptor 8 (TLR8) senses single-stranded RNA (ssRNA) and initiates innate immune responses. TLR8 requires proteolytic cleavage at the loop region (Z-loop) between leucine-rich repeat (LRR) 14 and LRR15 for its activation. However, the molecular basis of Z-loop processing remains unknown. T...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-03, Vol.113 (11), p.3012-3017
Hauptverfasser:	Tanji, Hiromi, Ohto, Umeharu, Motoi, Yuji, Shibata, Takuma, Miyake, Kensuke, Shimizu, Toshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Biochemistry Biological Sciences Crystallography Crystallography, X-Ray Dimerization Genes, Reporter HEK293 Cells Humans Immune system Ligands Models, Molecular Molecular Sequence Data NF-kappa B - metabolism Peptide Hydrolases - metabolism Protein Binding Protein Conformation Protein Processing, Post-Translational Protein Structure, Tertiary Proteins Proteolysis Recombinant Fusion Proteins - metabolism Ribonucleic acid RNA Sequence Alignment Toll-Like Receptor 8 - chemistry Toll-Like Receptor 8 - genetics Toll-Like Receptor 8 - metabolism
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