Mechanisms of backtrack recovery by RNA polymerases I and II

During DNA transcription, RNA polymerases often adopt inactive backtracked states. Recovery from backtracks can occur by 1D diffusion or cleavage of backtracked RNA, but how polymerases make this choice is unknown. Here, we use single-molecule optical tweezers experiments and stochastic theory to sh...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-03, Vol.113 (11), p.2946-2951
Hauptverfasser:	Lisica, Ana, Engel, Christoph, Jahnel, Marcus, Roldán, Édgar, Galburt, Eric A., Cramer, Patrick, Grill, Stephan W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Diffusion Enzymes Experiments Models, Chemical Motion Optical Tweezers Protein Binding Protein Subunits RNA polymerase RNA Polymerase I - chemistry RNA Polymerase I - metabolism RNA Polymerase II - chemistry RNA Polymerase II - genetics RNA Polymerase II - metabolism RNA, Fungal - biosynthesis RNA, Messenger - biosynthesis Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Sequence Deletion Stochastic models Stochastic Processes Time Transcription Elongation, Genetic - physiology Transcription factors Transcriptional Elongation Factors - chemistry Transcriptional Elongation Factors - metabolism
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