Regulation of calreticulin–major histocompatibility complex (MHC) class I interactions by ATP

The MHC class I peptide loading complex (PLC) facilitates the assembly of MHC class I molecules with peptides, but factors that regulate the stability and dynamics of the assembly complex are largely uncharacterized. Based on initial findings that ATP, in addition to MHC class I-specific peptide, is...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-10, Vol.112 (41), p.E5608-E5617
Hauptverfasser:	Wijeyesakere, Sanjeeva Joseph, Gagnon, Jessica K., Arora, Karunesh, Brooks, Charles L., Raghavan, Malini
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Adenosine triphosphatase Adenosine Triphosphate - genetics Adenosine Triphosphate - immunology Animals ATP Biological Sciences Calbindin 2 - genetics Calbindin 2 - immunology Calcium Calcium - immunology Endoplasmic Reticulum - genetics Endoplasmic Reticulum - immunology Experiments Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology Measurement Mice Mice, Knockout Molecules Peptides PNAS Plus Protein Binding - genetics Protein Binding - immunology Protein Structure, Tertiary Proteins
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