Endothelial microRNA-150 is an intrinsic suppressor of pathologic ocular neovascularization

Pathologic ocular neovascularization commonly causes blindness. It is critical to identify the factors altered in pathologically proliferating versus normally quiescent vessels to develop effective targeted therapeutics. MicroRNAs regulate both physiological and pathological angiogenesis through mod...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-09, Vol.112 (39), p.12163-12168
Hauptverfasser:	Liu, Chi-Hsiu, Sun, Ye, Li, Jie, Gong, Yan, Tian, Katherine T, Evans, Lucy P, Morss, Peyton C, Fredrick, Thomas W, Saba, Nicholas J, Chen, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Angiogenesis Animals Base Sequence Biological Sciences Blindness Blood vessels Cell Movement - drug effects Cell Proliferation - drug effects Choroidal Neovascularization - genetics Choroidal Neovascularization - metabolism Endothelial Cells - metabolism Frizzled Receptors - genetics Frizzled Receptors - metabolism Gene expression Gene Expression Regulation - drug effects HEK293 Cells Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Intravitreal Injections Laser Capture Microdissection Luciferases Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout MicroRNAs MicroRNAs - administration & dosage MicroRNAs - genetics MicroRNAs - metabolism MicroRNAs - pharmacology Molecular Sequence Data Pathology Physiology Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism Retinal Neovascularization - genetics Retinal Neovascularization - metabolism Retinal Vessels - cytology Retinal Vessels - metabolism
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