Outer-membrane translocation of bulky small molecules by passive diffusion

The outer membrane (OM) of gram-negative bacteria forms a protective layer around the cell that serves as a permeability barrier to prevent unrestricted access of noxious substances. The permeability barrier of the OM results partly from the limited pore diameters of OM diffusion channels. As a cons...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-06, Vol.112 (23), p.E2991-E2999
Hauptverfasser:	van den Berg, Bert, Bhamidimarri, Satya Prathyusha, Prajapati, Jigneshkumar Dahyabhai, Kleinekathöfer, Ulrich, Winterhalter, Mathias
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Outer Membrane Proteins - metabolism Binding Sites Biological Sciences Biological Transport Cell Membrane - metabolism Crystallography Crystallography, X-Ray cyclodextrins Cyclodextrins - metabolism Diffusion Gram-negative bacteria ions Klebsiella oxytoca Klebsiella oxytoca - metabolism metabolism Molecular Dynamics Simulation Molecules nutrients oligosaccharides Permeability PNAS Plus Simulation transporters
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