Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

The large class of adhesion G protein-coupled receptors (aGPCRs) bind extracellular matrix or neighboring cell-surface ligands to regulate organ and tissue development through an unknown activation mechanism. We examined aGPCR activation using two prototypical aGPCRs, GPR56 and GPR110. Active dissoc...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-05, Vol.112 (19), p.6194-6199
Hauptverfasser:	Stoveken, Hannah M., Hajduczok, Alexander G., Xu, Lei, Tall, Gregory G.
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion agonists Amino Acid Sequence Animals Binding Sites Biological Sciences Cell Adhesion Cell adhesion & migration Cell Line G-protein coupled receptors Glycoproteins HEK293 Cells Humans Insecta Ligands Models, Molecular Molecular Sequence Data Molecules neoplasms Oncogene Proteins - metabolism Peptides Peptides - chemistry Protein Binding Protein Structure, Tertiary Receptors, G-Protein-Coupled - metabolism Sequence Homology, Amino Acid Signal Transduction synthetic peptides Tissues
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