Gαᵢ₁ and Gαᵢ₃ regulate macrophage polarization by forming a complex containing CD14 and Gab1

Significance In this study, we demonstrate that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Gα ᵢ₁/₃) regulate the downstream signaling pathways of Toll-like receptor 4 (TLR4). We show that Gα ᵢ₁/₃ form complexes containing the pattern recognition receptor (PRR) CD14 and grow...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-04, Vol.112 (15), p.4731-4736
Hauptverfasser:	Li, Xianjing, Wang, Duowei, Chen, Zhen, Lu, Ermei, Wang, Zhuo, Duan, Jingjing, Tian, Wei, Wang, Yun, You, Linjun, Zou, Yulian, Cheng, Yan, Zhu, Qingyi, Wan, Xiaojian, Xi, Tao, Jiang, Meisheng, Han, Yuyuan, Cao, Cong, Birnbaumer, Lutz, Chu, Wen-Ming, Yang, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Biological Sciences Blotting, Western Cell Line, Tumor Cells, Cultured endocytosis Endocytosis - drug effects G-proteins GTP-Binding Protein alpha Subunits, Gi-Go - genetics GTP-Binding Protein alpha Subunits, Gi-Go - metabolism Humans inflammation Interleukin-12 - metabolism Interleukin-6 - metabolism Lipopolysaccharide Receptors - genetics Lipopolysaccharide Receptors - metabolism Lipopolysaccharides - pharmacology macrophages Macrophages - drug effects Macrophages - metabolism Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Mice, 129 Strain Mice, Knockout Microscopy, Confocal Mitogen-Activated Protein Kinases - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism plasma membrane Protein Binding - drug effects Protein Subunits - genetics Protein Subunits - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference signal transduction Survival Analysis Toll-like receptor 4 Toll-Like Receptor 4 - metabolism transcription factor NF-kappa B Tumor Necrosis Factor-alpha - metabolism
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