Chemical synthesis of the ATAD2 bromodomain

Due to the emerging importance of the bromodomain binding region in the study of epigenetic effectors and the vast implications for a wide variety of human disease, the bromodomain region of human ATPase family AAA+ (ATPases associated with diverse cellular activities) domain-containing protein 2 (A...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-02, Vol.111 (8), p.2891-2896
Hauptverfasser:	Creecha, Gardner S., Paresi, Chelsea, Li, Yue-Ming, Danishefsky, Samuel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adenosine triphosphatases Adenosine Triphosphatases - chemical synthesis adenosinetriphosphatase alanine Amino acids ATPases Associated with Diverse Cellular Activities Chemical synthesis Chromatin Chromatography, High Pressure Liquid cysteine DNA-Binding Proteins - chemical synthesis Epigenetics glutamic acid high performance liquid chromatography Histones human diseases Humans Hydrolysis Kinetics leucine Ligation Magnetic Resonance Spectroscopy Mass Spectrometry Peptide Fragments - chemistry Peptides Phosphates Physical Sciences Protein Structure, Tertiary Proteins Solid-Phase Synthesis Techniques - methods synthesis Tumors
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