Noninvasive positron emission tomography and fluorescence imaging of CD133⁺ tumor stem cells

A technology that visualizes tumor stem cells with clinically relevant tracers could have a broad impact on cancer diagnosis and treatment. The AC133 epitope of CD133 currently is one of the best-characterized tumor stem cell markers for many intra- and extracranial tumor entities. Here we demonstra...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-02, Vol.111 (6), p.E692-E701
Hauptverfasser:	Gaedicke, Simone, Braun, Friederike, Prasad, Shruthi, Machein, Marcia, Firat, Elke, Hettich, Michael, Gudihal, Ravindra, Zhu, Xuekai, Klingner, Kerstin, Schüler, Julia, Herold-Mende, Christel C, Grosu, Anca-Ligia, Behe, Martin, Weber, Wolfgang, Mäcke, Helmut, Niedermann, Gabriele
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Animals Antigens, CD - immunology Biological Sciences Brain Neoplasms - diagnostic imaging Cancer epitopes Fluorescence Glioblastoma - diagnostic imaging Glycoproteins - immunology Heterografts image analysis Mice monitoring Multimodal Imaging neoplasms Neoplastic Stem Cells - immunology Peptides - immunology PNAS Plus positron-emission tomography Positron-Emission Tomography - methods Stem cells tissues Tomography Tomography, X-Ray Computed tracer techniques Tumors
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