Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence

Clostridium difficile causes antibiotic-associated diarrhea and pseudomembranous colitis by the actions of Rho-glucosylating toxins A and B. Recently identified hypervirulent strains, which are associated with increased morbidity and mortality, additionally produce the actin-ADP–ribosylating toxin C...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-02, Vol.111 (6), p.2313-2318
Hauptverfasser:	Schwan, Carsten, Kruppke, Anna S., Nölke, Thilo, Schumacher, Lucas, Koch-Nolte, Friedrich, Kudryashev, Mikhail, Stahlberg, Henning, Aktories, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Antibiotics Bacterial Adhesion Bacterial Toxins - toxicity Biological Sciences Biological Transport Caco 2 cells Calcium Calcium Signaling Cell membranes Clostridium difficile Clostridium difficile - metabolism Clostridium difficile - pathogenicity Endoplasmic Reticulum - drug effects Enterotoxins - toxicity Epithelial cells Fibronectins - metabolism Gram-positive bacteria Humans Microtubules Microtubules - drug effects Proteins Quantification Secretion Toxins
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