Topological sensitivity analysis for systems biology

Significance Mathematical models are widely used to study natural systems. They allow us to test and generate hypotheses, and help us to understand the processes underlying the observed behavior. However, such models are, by necessity, simplified representations of the true systems, so it is critica...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-12, Vol.111 (52), p.18507-18512
Hauptverfasser:	Babtie, Ann C., Kirk, Paul, Stumpf, Michael P. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Architectural models Biological Sciences Datasets Dynamic modeling Inference Mathematical models Modeling Models, Biological Odes Ordinary differential equations Parametric models Photochemistry Physical properties Physical Sciences Sensitivity analysis Simulations Statistical inference Systems Biology - methods Topology
Online-Zugang:	Volltext
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