Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals
Significance Efforts to develop an efficacious HIV vaccine have been unsuccessful to date. Efficacy trials have reported that recombinant Ad5 (rAd5)-HIV vaccines were not efficacious and unexpectedly associated with excess HIV infection in vaccine recipients. Understanding the underlying mechanisms...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2014-09, Vol.111 (37), p.13439-13444 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 13444 |
|---|---|
| container_issue | 37 |
| container_start_page | 13439 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 111 |
| creator | Hu, Haitao Eller, Michael A. Zafar, Shah Zhou, Yu Gu, Mengnan Wei, Zhi Currier, Jeffrey R. Marovich, Mary A. Kibuuka, Hannah N. Bailer, Robert T. Koup, Richard A. Robb, Merlin L. Michael, Nelson L. Kim, Jerome H. Ratto-Kim, Silvia |
| description | Significance Efforts to develop an efficacious HIV vaccine have been unsuccessful to date. Efficacy trials have reported that recombinant Ad5 (rAd5)-HIV vaccines were not efficacious and unexpectedly associated with excess HIV infection in vaccine recipients. Understanding the underlying mechanisms is urgent and will further HIV vaccine design. By comparing human CD4 T cells specific to Ad5 and CMV, we report that natural exposure- or vaccine-induced Ad5-specific CD4 T cells are highly susceptible to HIV compared with CMV-specific CD4 T cells and selectively manifest a Th17-like proinflammatory phenotype. Our findings suggest a potential mechanism for rAd5-associated excess HIV infections in vaccine recipients and highlight that testing HIV susceptibility of vaccine-generated CD4 T cells may have utility before vaccine evaluation in human trials. |
| doi_str_mv | 10.1073/pnas.1400446111 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pnas_</sourceid><recordid>TN_cdi_pnas_primary_111_37_13439</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>43043488</jstor_id><sourcerecordid>43043488</sourcerecordid><originalsourceid>FETCH-LOGICAL-c558t-8931a56b1783dc185906c930e2d4db5533c75c1f3651356f6fea7448daa7b7453</originalsourceid><addsrcrecordid>eNqFkk1v1DAQhiMEokvhzAmwxIVL2pn4I_YFqVo-WqkSSLRcLcdxWq927W2crNhfwN_G6S7Lx6WnkTzP-2pm_BbFS4QThJqeroNJJ8gAGBOI-KiYISgsBVPwuJgBVHUpWcWOimcpLQBAcQlPi6OKo6qhlrPi59feda53YfBmSXzonB18DCR25HZcmUDOWl6mtbO-85bMPzByRaxbLhNptuT84nuWTAgJZhh7s1xuifuxjsm1xISW9M7GVeODCcO90STYGGvzy5ARH1q_8e1olul58aTLxb3Y1-Pi-tPHq_l5efnl88X87LK0nMuhlIqi4aLBWtLWouQKhFUUXNWytuGcUltzix0VHCkXneicqRmTrTF1UzNOj4v3O9_12Kxca_PieWy97v3K9Fsdjdf_doK_1TdxoxkKpWSVDd7tDfp4N7o06JVP00VMcHFMGiVQyFMpeBgVKJEplPRhlAsKAun9AG__Qxdx7EM-2kSxbMiriTrdUbaPKeU_PqyIoKfo6Ck6-k90suL135c58L-zkgGyByblwQ5R01ojZVRl5NUOWaQh9geGUWCUycniza7fmajNTe-Tvv5WAQoAZIzn7X4BHofa8w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1564149522</pqid></control><display><type>article</type><title>Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Hu, Haitao ; Eller, Michael A. ; Zafar, Shah ; Zhou, Yu ; Gu, Mengnan ; Wei, Zhi ; Currier, Jeffrey R. ; Marovich, Mary A. ; Kibuuka, Hannah N. ; Bailer, Robert T. ; Koup, Richard A. ; Robb, Merlin L. ; Michael, Nelson L. ; Kim, Jerome H. ; Ratto-Kim, Silvia</creator><creatorcontrib>Hu, Haitao ; Eller, Michael A. ; Zafar, Shah ; Zhou, Yu ; Gu, Mengnan ; Wei, Zhi ; Currier, Jeffrey R. ; Marovich, Mary A. ; Kibuuka, Hannah N. ; Bailer, Robert T. ; Koup, Richard A. ; Robb, Merlin L. ; Michael, Nelson L. ; Kim, Jerome H. ; Ratto-Kim, Silvia</creatorcontrib><description>Significance Efforts to develop an efficacious HIV vaccine have been unsuccessful to date. Efficacy trials have reported that recombinant Ad5 (rAd5)-HIV vaccines were not efficacious and unexpectedly associated with excess HIV infection in vaccine recipients. Understanding the underlying mechanisms is urgent and will further HIV vaccine design. By comparing human CD4 T cells specific to Ad5 and CMV, we report that natural exposure- or vaccine-induced Ad5-specific CD4 T cells are highly susceptible to HIV compared with CMV-specific CD4 T cells and selectively manifest a Th17-like proinflammatory phenotype. Our findings suggest a potential mechanism for rAd5-associated excess HIV infections in vaccine recipients and highlight that testing HIV susceptibility of vaccine-generated CD4 T cells may have utility before vaccine evaluation in human trials.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1400446111</identifier><identifier>PMID: 25197078</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Adenoviridae - immunology ; Adenovirus ; Adenoviruses ; AIDS vaccines ; AIDS Vaccines - immunology ; Antigens ; Biological Sciences ; CD4-positive T-lymphocytes ; CD4-Positive T-Lymphocytes - immunology ; Clinical trials ; Cytokines ; Cytomegalovirus - immunology ; Disease Susceptibility ; Genotype & phenotype ; Healthy Volunteers ; HIV ; HIV infections ; HIV Infections - immunology ; HIV Infections - virology ; HIV-1 - immunology ; Human cytomegalovirus ; human diseases ; Human immunodeficiency virus ; Humans ; Infections ; Inflammation - pathology ; Interleukin-17 - biosynthesis ; Interleukin-2 - biosynthesis ; Intestinal Mucosa - pathology ; Phenotype ; Phenotypes ; Recombination, Genetic - genetics ; Species Specificity ; T cell receptors ; T lymphocytes ; Th17 Cells - immunology ; Vaccination ; vaccine development ; Vaccines</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (37), p.13439-13444</ispartof><rights>copyright © 1993–2008 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Sep 16, 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-8931a56b1783dc185906c930e2d4db5533c75c1f3651356f6fea7448daa7b7453</citedby><cites>FETCH-LOGICAL-c558t-8931a56b1783dc185906c930e2d4db5533c75c1f3651356f6fea7448daa7b7453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/111/37.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/43043488$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/43043488$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25197078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Haitao</creatorcontrib><creatorcontrib>Eller, Michael A.</creatorcontrib><creatorcontrib>Zafar, Shah</creatorcontrib><creatorcontrib>Zhou, Yu</creatorcontrib><creatorcontrib>Gu, Mengnan</creatorcontrib><creatorcontrib>Wei, Zhi</creatorcontrib><creatorcontrib>Currier, Jeffrey R.</creatorcontrib><creatorcontrib>Marovich, Mary A.</creatorcontrib><creatorcontrib>Kibuuka, Hannah N.</creatorcontrib><creatorcontrib>Bailer, Robert T.</creatorcontrib><creatorcontrib>Koup, Richard A.</creatorcontrib><creatorcontrib>Robb, Merlin L.</creatorcontrib><creatorcontrib>Michael, Nelson L.</creatorcontrib><creatorcontrib>Kim, Jerome H.</creatorcontrib><creatorcontrib>Ratto-Kim, Silvia</creatorcontrib><title>Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Significance Efforts to develop an efficacious HIV vaccine have been unsuccessful to date. Efficacy trials have reported that recombinant Ad5 (rAd5)-HIV vaccines were not efficacious and unexpectedly associated with excess HIV infection in vaccine recipients. Understanding the underlying mechanisms is urgent and will further HIV vaccine design. By comparing human CD4 T cells specific to Ad5 and CMV, we report that natural exposure- or vaccine-induced Ad5-specific CD4 T cells are highly susceptible to HIV compared with CMV-specific CD4 T cells and selectively manifest a Th17-like proinflammatory phenotype. Our findings suggest a potential mechanism for rAd5-associated excess HIV infections in vaccine recipients and highlight that testing HIV susceptibility of vaccine-generated CD4 T cells may have utility before vaccine evaluation in human trials.</description><subject>Adenoviridae - immunology</subject><subject>Adenovirus</subject><subject>Adenoviruses</subject><subject>AIDS vaccines</subject><subject>AIDS Vaccines - immunology</subject><subject>Antigens</subject><subject>Biological Sciences</subject><subject>CD4-positive T-lymphocytes</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Clinical trials</subject><subject>Cytokines</subject><subject>Cytomegalovirus - immunology</subject><subject>Disease Susceptibility</subject><subject>Genotype & phenotype</subject><subject>Healthy Volunteers</subject><subject>HIV</subject><subject>HIV infections</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - immunology</subject><subject>Human cytomegalovirus</subject><subject>human diseases</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Inflammation - pathology</subject><subject>Interleukin-17 - biosynthesis</subject><subject>Interleukin-2 - biosynthesis</subject><subject>Intestinal Mucosa - pathology</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Recombination, Genetic - genetics</subject><subject>Species Specificity</subject><subject>T cell receptors</subject><subject>T lymphocytes</subject><subject>Th17 Cells - immunology</subject><subject>Vaccination</subject><subject>vaccine development</subject><subject>Vaccines</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEokvhzAmwxIVL2pn4I_YFqVo-WqkSSLRcLcdxWq927W2crNhfwN_G6S7Lx6WnkTzP-2pm_BbFS4QThJqeroNJJ8gAGBOI-KiYISgsBVPwuJgBVHUpWcWOimcpLQBAcQlPi6OKo6qhlrPi59feda53YfBmSXzonB18DCR25HZcmUDOWl6mtbO-85bMPzByRaxbLhNptuT84nuWTAgJZhh7s1xuifuxjsm1xISW9M7GVeODCcO90STYGGvzy5ARH1q_8e1olul58aTLxb3Y1-Pi-tPHq_l5efnl88X87LK0nMuhlIqi4aLBWtLWouQKhFUUXNWytuGcUltzix0VHCkXneicqRmTrTF1UzNOj4v3O9_12Kxca_PieWy97v3K9Fsdjdf_doK_1TdxoxkKpWSVDd7tDfp4N7o06JVP00VMcHFMGiVQyFMpeBgVKJEplPRhlAsKAun9AG__Qxdx7EM-2kSxbMiriTrdUbaPKeU_PqyIoKfo6Ck6-k90suL135c58L-zkgGyByblwQ5R01ojZVRl5NUOWaQh9geGUWCUycniza7fmajNTe-Tvv5WAQoAZIzn7X4BHofa8w</recordid><startdate>20140916</startdate><enddate>20140916</enddate><creator>Hu, Haitao</creator><creator>Eller, Michael A.</creator><creator>Zafar, Shah</creator><creator>Zhou, Yu</creator><creator>Gu, Mengnan</creator><creator>Wei, Zhi</creator><creator>Currier, Jeffrey R.</creator><creator>Marovich, Mary A.</creator><creator>Kibuuka, Hannah N.</creator><creator>Bailer, Robert T.</creator><creator>Koup, Richard A.</creator><creator>Robb, Merlin L.</creator><creator>Michael, Nelson L.</creator><creator>Kim, Jerome H.</creator><creator>Ratto-Kim, Silvia</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20140916</creationdate><title>Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals</title><author>Hu, Haitao ; Eller, Michael A. ; Zafar, Shah ; Zhou, Yu ; Gu, Mengnan ; Wei, Zhi ; Currier, Jeffrey R. ; Marovich, Mary A. ; Kibuuka, Hannah N. ; Bailer, Robert T. ; Koup, Richard A. ; Robb, Merlin L. ; Michael, Nelson L. ; Kim, Jerome H. ; Ratto-Kim, Silvia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c558t-8931a56b1783dc185906c930e2d4db5533c75c1f3651356f6fea7448daa7b7453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adenoviridae - immunology</topic><topic>Adenovirus</topic><topic>Adenoviruses</topic><topic>AIDS vaccines</topic><topic>AIDS Vaccines - immunology</topic><topic>Antigens</topic><topic>Biological Sciences</topic><topic>CD4-positive T-lymphocytes</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Clinical trials</topic><topic>Cytokines</topic><topic>Cytomegalovirus - immunology</topic><topic>Disease Susceptibility</topic><topic>Genotype & phenotype</topic><topic>Healthy Volunteers</topic><topic>HIV</topic><topic>HIV infections</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - immunology</topic><topic>Human cytomegalovirus</topic><topic>human diseases</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infections</topic><topic>Inflammation - pathology</topic><topic>Interleukin-17 - biosynthesis</topic><topic>Interleukin-2 - biosynthesis</topic><topic>Intestinal Mucosa - pathology</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Recombination, Genetic - genetics</topic><topic>Species Specificity</topic><topic>T cell receptors</topic><topic>T lymphocytes</topic><topic>Th17 Cells - immunology</topic><topic>Vaccination</topic><topic>vaccine development</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Haitao</creatorcontrib><creatorcontrib>Eller, Michael A.</creatorcontrib><creatorcontrib>Zafar, Shah</creatorcontrib><creatorcontrib>Zhou, Yu</creatorcontrib><creatorcontrib>Gu, Mengnan</creatorcontrib><creatorcontrib>Wei, Zhi</creatorcontrib><creatorcontrib>Currier, Jeffrey R.</creatorcontrib><creatorcontrib>Marovich, Mary A.</creatorcontrib><creatorcontrib>Kibuuka, Hannah N.</creatorcontrib><creatorcontrib>Bailer, Robert T.</creatorcontrib><creatorcontrib>Koup, Richard A.</creatorcontrib><creatorcontrib>Robb, Merlin L.</creatorcontrib><creatorcontrib>Michael, Nelson L.</creatorcontrib><creatorcontrib>Kim, Jerome H.</creatorcontrib><creatorcontrib>Ratto-Kim, Silvia</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Haitao</au><au>Eller, Michael A.</au><au>Zafar, Shah</au><au>Zhou, Yu</au><au>Gu, Mengnan</au><au>Wei, Zhi</au><au>Currier, Jeffrey R.</au><au>Marovich, Mary A.</au><au>Kibuuka, Hannah N.</au><au>Bailer, Robert T.</au><au>Koup, Richard A.</au><au>Robb, Merlin L.</au><au>Michael, Nelson L.</au><au>Kim, Jerome H.</au><au>Ratto-Kim, Silvia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2014-09-16</date><risdate>2014</risdate><volume>111</volume><issue>37</issue><spage>13439</spage><epage>13444</epage><pages>13439-13444</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Significance Efforts to develop an efficacious HIV vaccine have been unsuccessful to date. Efficacy trials have reported that recombinant Ad5 (rAd5)-HIV vaccines were not efficacious and unexpectedly associated with excess HIV infection in vaccine recipients. Understanding the underlying mechanisms is urgent and will further HIV vaccine design. By comparing human CD4 T cells specific to Ad5 and CMV, we report that natural exposure- or vaccine-induced Ad5-specific CD4 T cells are highly susceptible to HIV compared with CMV-specific CD4 T cells and selectively manifest a Th17-like proinflammatory phenotype. Our findings suggest a potential mechanism for rAd5-associated excess HIV infections in vaccine recipients and highlight that testing HIV susceptibility of vaccine-generated CD4 T cells may have utility before vaccine evaluation in human trials.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>25197078</pmid><doi>10.1073/pnas.1400446111</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (37), p.13439-13444 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pnas_primary_111_37_13439 |
| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Adenoviridae - immunology Adenovirus Adenoviruses AIDS vaccines AIDS Vaccines - immunology Antigens Biological Sciences CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - immunology Clinical trials Cytokines Cytomegalovirus - immunology Disease Susceptibility Genotype & phenotype Healthy Volunteers HIV HIV infections HIV Infections - immunology HIV Infections - virology HIV-1 - immunology Human cytomegalovirus human diseases Human immunodeficiency virus Humans Infections Inflammation - pathology Interleukin-17 - biosynthesis Interleukin-2 - biosynthesis Intestinal Mucosa - pathology Phenotype Phenotypes Recombination, Genetic - genetics Species Specificity T cell receptors T lymphocytes Th17 Cells - immunology Vaccination vaccine development Vaccines |
| title | Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T06%3A24%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pnas_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preferential%20infection%20of%20human%20Ad5-specific%20CD4%20T%20cells%20by%20HIV%20in%20Ad5%20naturally%20exposed%20and%20recombinant%20Ad5-HIV%20vaccinated%20individuals&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Hu,%20Haitao&rft.date=2014-09-16&rft.volume=111&rft.issue=37&rft.spage=13439&rft.epage=13444&rft.pages=13439-13444&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.1400446111&rft_dat=%3Cjstor_pnas_%3E43043488%3C/jstor_pnas_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1564149522&rft_id=info:pmid/25197078&rft_jstor_id=43043488&rfr_iscdi=true |