Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

Muscle insulin resistance is a key feature of obesity and type 2 diabetes and is strongly associated with increased intramyocellular lipid content and inflammation. However, the cellular and molecular mechanisms responsible for causing muscle insulin resistance in humans are still unclear. To addres...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-07, Vol.111 (26), p.9597-9602
Hauptverfasser:	Szendroedi, Julia, Yoshimura, Toru, Phielix, Esther, Koliaki, Chrysi, Marcucci, Mellissa, Zhang, Dongyan, Jelenik, Tomas, Müller, Janette, Herder, Christian, Nowotny, Peter, Shulman, Gerald I., Roden, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	adiponectin Analysis of Variance Biological Sciences biopsy Blood Chemical Analysis Calorimetry, Indirect Ceramides Diabetes Mellitus, Type 2 - physiopathology diacylglycerols Diglycerides Diglycerides - metabolism Enzyme Activation - physiology Glucose Clamp Technique Humans inflammation Insulin Insulin resistance Insulin Resistance - physiology interleukin-6 Isoenzymes - metabolism lipid content Lipids Muscles Muscles - metabolism Muscles - physiopathology noninsulin-dependent diabetes mellitus Obesity pathogenesis Phosphorylation protein kinase C Protein Kinase C - metabolism Protein Kinase C-theta retinol-binding protein serine signal transducing adaptor proteins Skeletal muscle Type 2 diabetes mellitus tyrosine
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